{"product_id":"kmt5c-antibody-suv420h2-bha17128159","title":"KMT5C Antibody \/ SUV420H2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eKMT5C Antibody \/ SUV420H2 is an antibody targeting \u003cstrong\u003eSUV420H2\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SUV420H2.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human, Mouse.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB, FACS (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eKMT5C, also called Suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 and Suv4-20h2, belongs to a family of proteins called lysine methyltransferases, which are enzymes that play a key role in the modification of histone proteins. Histones are proteins that help package and organize DNA in the nucleus of a cell, and modifications to these proteins can have profound effects on gene expression. Studies have shown that KMT5C specifically targets histone H4 lysine 20 (H4K20) for methylation, which has been linked to the regulation of gene transcription and DNA replication. Dysregulation of this process has been implicated in various diseases, including cancer and developmental disorders. In cancer, aberrant expression of KMT5C has been observed in several tumor types, and its overexpression has been associated with poor prognosis. Mutations in the KMT5C gene have been linked to developmental disorders, such as intellectual disability and autism spectrum disorders. These findings highlight the importance of KMT5C in brain development and function, and provide new insights into the underlying mechanisms of these conditions.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eFlow cytometry: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry Q86Y97 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q86Y97 - Gene search: SUV420H2 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SUV420H2 - Ensembl search: SUV420H2 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SUV420H2 - PubMed search: SUV420H2 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SUV420H2+antibody - Reactome search: SUV420H2 — Reactome — https:\/\/reactome.org\/content\/query?q=SUV420H2 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.05 ml","offer_id":53046409560429,"sku":"F55096-0.05ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.2 ml","offer_id":53046471197037,"sku":"F55096-0.2ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9970a27a-8511-4580-93dc-325437c6060d.jpg?v=1772000495","url":"https:\/\/www.ebiohippo.com\/products\/kmt5c-antibody-suv420h2-bha17128159","provider":"BioHippo","version":"1.0","type":"link"}