{"product_id":"kt5720-bhb21300192","title":"KT5720","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9- meth yl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]py rrolo[3,4- i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 108068-98-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C32H31N3O5.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 100-500 nM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PKA\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Semi-synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e KT5720 is a potent and specific inhibitor of PKA (IC50 = 56 nM)1.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eKT5720 is a semi-synthetic derivative of K525a. It is a cell-permeable, selective inhibitor of cAMP-dependent protein kinase (PKA; IC50 = 56 nM). No significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (MLCK), was observed.1 KT5720 was used to examine the role of PKA in various cellular events such as cell adhesion,2 neurite branching,3 anterograde axonal transport,4 memory consolidation,5,6 and regulation of transcription by cyclic AMP-dependent response element-binding protein (CREB).7\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"0.1 mg \/ 1","offer_id":53249709998445,"sku":"K-190-0P1MG-1","price":170.0,"currency_code":"USD","in_stock":true},{"title":"0.25 mg \/ 1","offer_id":53311562482029,"sku":"K-190-0P25MG-1","price":383.0,"currency_code":"USD","in_stock":true},{"title":"0.5 mg \/ 1","offer_id":53311562514797,"sku":"K-190-0P5MG-1","price":707.0,"currency_code":"USD","in_stock":true},{"title":"50 mcg \/ 1","offer_id":53311562547565,"sku":"K-190-50MCG-1","price":92.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/K-190.gif?v=1778544438","url":"https:\/\/www.ebiohippo.com\/products\/kt5720-bhb21300192","provider":"BioHippo","version":"1.0","type":"link"}