{"product_id":"ky19382-bhb20447022","title":"KY19382","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n  \u003ch2\u003eCompound Overview\u003c\/h2\u003e\n  \u003cp\u003e\u003cstrong\u003eKY19382\u003c\/strong\u003e (CAS 2226664-93-1) is a research-grade small molecule supplied by TargetMol.\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eAlternative names:\u003c\/strong\u003e 2H-Indol-2-one, 5,6-dichloro-3-(1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene)-1,3-dihydro-Ky19382\u003c\/p\u003e\n  \u003ch2\u003ePhysical Properties\u003c\/h2\u003e\n  \u003ctable class=\"bhp-spec-table\"\u003e\n    \u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e2226664-93-1\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eC17H11Cl2N3O2\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e360.19 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd style=\"font-size:13px;word-break:break-all\"\u003eO=C1C(C=2C(N1)=CC(Cl)=C(Cl)C2)=C3C(=NOC)C=4C(N3)=CC=CC4\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003ctd\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom Temperature (RT)\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003c\/table\u003e\n  \u003ch2\u003eBiological Activity\u003c\/h2\u003e\n  \u003cp\u003eKY19382 (2H-Indol-2-one, 5,6-dichloro-3-(1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene)-1,3-dihydro-Ky19382) is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3beta( IC50s of 19 and 10 nM, respectively). It activates Wnt\/beta-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3beta activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases.\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eTarget(s):\u003c\/strong\u003e Others, Wnt\/beta-catenin, GSK-3\u003c\/p\u003e\n  \u003cp\u003e\u003cstrong\u003eSignaling pathway(s):\u003c\/strong\u003e Cytoskeletal Signaling, PI3K\/Akt\/mTOR signaling, Others, Stem Cells\u003c\/p\u003e\n  \u003ch2\u003eSafety \u0026amp; Regulatory\u003c\/h2\u003e\n  \u003cdiv class=\"bhp-warning-box\"\u003e\n    \u003cp\u003e\u003cstrong\u003eFor Research Use Only (RUO).\u003c\/strong\u003e Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.\u003c\/p\u003e\n  \u003c\/div\u003e\n\u003c\/div\u003e","brand":"TargetMol","offers":[{"title":"1 mg","offer_id":53327300886893,"sku":"T9025-1MG","price":100.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53327324905837,"sku":"T9025-5MG","price":207.0,"currency_code":"USD","in_stock":true},{"title":"1 mL x 10 mM (in DMSO)","offer_id":53327324938605,"sku":"T9025-1MLX10MM","price":255.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53327324971373,"sku":"T9025-10MG","price":369.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53327325004141,"sku":"T9025-25MG","price":622.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53327325036909,"sku":"T9025-50MG","price":885.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53327325069677,"sku":"T9025-100MG","price":1190.0,"currency_code":"USD","in_stock":true},{"title":"500 mg","offer_id":53327325102445,"sku":"T9025-500MG","price":2430.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CgoaEGayN6OEI6LKAAAAAHgU4ZM347.png?v=1778722345","url":"https:\/\/www.ebiohippo.com\/products\/ky19382-bhb20447022","provider":"BioHippo","version":"1.0","type":"link"}