{"product_id":"l-ascorbic-acid-bhb21300198","title":"L-Ascorbic acid","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 3-Oxo-L-gulofuranolactone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Vitamin C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 50-81-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C6H8O6.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 10 nM - 5 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Water. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Water. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e T-type Ca2+ channels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e IC50 of 6.5 µM on T-type current of rat DRG neurons1. IC50s of 10 and 25 nM on cloned CaV3.2 channels from human and rat, respectively1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e Vitamin C\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eThe T-type calcium channel belongs to the voltage-gated Ca2+ channel (CaV) family. \"T\" stands for transient, referring to the length of activation. As with other sub-types of voltage-gated Ca2+ channels, the α1 subunit is the one that determines most of the channel's properties. T-type calcium channels may contain one of three α1 subunits, α1G (CaV3.1), α1H (CaV3.2) or α1I (CaV3.3)1-3.T-type Ca2+ channels are involved in the control of neuronal excitability and their gating can be modulated by a variety of redox agents4.L-Ascorbic acid (ascorbate) is an endogenous redox agent that selectively inhibits native CaV3.2 channels in the peripheral and central neurons4.L-Ascorbic acid has an IC50 of 6.5 µM on T-type current of rat DRG neurons, and IC50s of 10 and 25 nM on cloned CaV3.2 channels from human and rat, respectively4.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 g \/ 1","offer_id":53249709965677,"sku":"L-140-10G-1","price":37.0,"currency_code":"USD","in_stock":true},{"title":"100 g \/ 1","offer_id":53311563170157,"sku":"L-140-100G-1","price":75.0,"currency_code":"USD","in_stock":true},{"title":"25 g \/ 1","offer_id":53311563202925,"sku":"L-140-25G-1","price":45.0,"currency_code":"USD","in_stock":true},{"title":"50 g \/ 1","offer_id":53311563235693,"sku":"L-140-50G-1","price":55.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/L-140_gr.gif?v=1778544435","url":"https:\/\/www.ebiohippo.com\/products\/l-ascorbic-acid-bhb21300198","provider":"BioHippo","version":"1.0","type":"link"}