{"product_id":"lamin-a-c-rabbit-pab-bha15201696","title":"Lamin A\/C rabbit pAb","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003ePolyclonal Primary Antibody\u003c\/span\u003e\n\u003cp\u003eAnti-Lamin A\/C rabbit pAb antibody (, -derived) validated for use in multiple research applications. Targets Lamin A\/C rabbit pAb in validated species samples.\u003c\/p\u003e\n\n\n\u003ch2\u003eAntibody Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\n\u003c\/table\u003e\n\n\u003ch2\u003eScientific Background\u003c\/h2\u003e\n\u003cp\u003elamin A\/C(LMNA) Homo sapiens    The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative …\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSubcellular Location:\u003c\/strong\u003e Nucleus . Nucleus envelope . Nucleus lamina. Nucleus, nucleoplasm. Nucleus matrix . Farnesylation of prelamin-A\/C facilitates nuclear envelope targeting and subsequent cleavage by ZMPSTE24\/FACE1 to remove the farnesyl group produces mature lamin-A\/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A\/C.; [Isoform C]: Nucleus speckle .\u003c\/p\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\n\u003cstrong\u003eFor Research Use Only (RUO).\u003c\/strong\u003e Not intended for diagnostic or therapeutic procedures. Handle with standard laboratory biosafety precautions.\u003c\/div\u003e\n\u003ch2\u003eRelated Products\u003c\/h2\u003e\n\u003cp\u003eExplore our complete catalog of antibodies, ELISA kits, and life science research reagents at BioHippo.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"ELK Biotechnology","offers":[{"title":"50 uL","offer_id":53336230920557,"sku":"ES2695-50UL","price":192.4,"currency_code":"USD","in_stock":true},{"title":"100 uL","offer_id":53336235049325,"sku":"ES2695-100UL","price":322.4,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ES2695-c-1.jpg?v=1778915810","url":"https:\/\/www.ebiohippo.com\/products\/lamin-a-c-rabbit-pab-bha15201696","provider":"BioHippo","version":"1.0","type":"link"}