{"product_id":"lgals3bp-antibody-galectin-3-binding-protein-bha17136120","title":"LGALS3BP Antibody \/ Galectin-3-binding protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eLGALS3BP Antibody \/ Galectin-3-binding protein is a anti-LGALS3BP Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e LGALS3BP\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eLGALS3BP antibody detects Galectin-3-binding protein, a secreted glycoprotein involved in cell adhesion, immune modulation, and tumor metastasis. The UniProt recommended name is Galectin-3-binding protein (LGALS3BP). Also known as 90K or Mac-2-binding protein, this multifunctional glycoprotein mediates extracellular interactions that influence immune cell communication, matrix remodeling, and viral infection processes.\u003cbr\u003e\u003cbr\u003eFunctionally, LGALS3BP antibody identifies a 585-amino-acid secreted protein characterized by a heavily glycosylated scavenger receptor cysteine-rich (SRCR)-like domain. LGALS3BP interacts with galectins, integrins, and extracellular matrix components such as fibronectin and laminin to facilitate cell adhesion and migration. It modulates immune signaling by promoting cytokine release, dendritic cell maturation, and macrophage activation. In the tumor microenvironment, LGALS3BP enhances metastatic potential by regulating cell-cell interactions and immune evasion mechanisms.\u003cbr\u003e\u003cbr\u003eThe LGALS3BP gene is located on chromosome 17q25.3 and is expressed in immune cells, epithelial tissues, and cancerous lesions. Its secretion increases in inflammatory conditions, viral infections, and malignancies, where it serves as a biomarker of immune activation and tumor progression.\u003cbr\u003e\u003cbr\u003ePathologically, elevated LGALS3BP levels have been associated with breast, prostate, and lung cancers, as well as HIV infection and autoimmune diseases. In cancer, high expression correlates with increased invasiveness and poor prognosis due to its roles in matrix remodeling and immune suppression. In infectious diseases, LGALS3BP can act as a host restriction factor that limits viral replication. Research using LGALS3BP antibody supports studies in cancer biology, immunology, and extracellular matrix signaling.\u003cbr\u003e\u003cbr\u003eLGALS3BP antibody is validated for western blotting, immunohistochemistry, and ELISA to detect secreted glycoproteins. \u003cbr\u003e\u003cbr\u003eStructurally, Galectin-3-binding protein forms disulfide-linked oligomers and contains multiple N-linked glycosylation sites critical for stability and receptor binding. Its SRCR-like domain mediates carbohydrate and protein interactions that underpin its diverse functional roles. This antibody enables analysis of LGALS3BP's involvement in cell communication, matrix adhesion, and immune regulation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=LGALS3BP - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=LGALS3BP - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=LGALS3BP - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/LGALS3BP - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=LGALS3BP+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047319527789,"sku":"FY13218","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_11002dbe-9eff-4b5d-baf5-c46f4c4c9530.jpg?v=1782237097","url":"https:\/\/www.ebiohippo.com\/products\/lgals3bp-antibody-galectin-3-binding-protein-bha17136120","provider":"BioHippo","version":"1.0","type":"link"}