{"product_id":"lgals7-7b-antibody-galectin-7-bha17135671","title":"LGALS7\/7B Antibody \/ Galectin 7","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eLGALS7\/7B Antibody \/ Galectin 7 is a anti-7B Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e 7B\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eLGALS7\/7B antibody detects Galectin-7 (encoded by LGALS7 and its paralog LGALS7B), a beta-galactoside-binding lectin that regulates epithelial differentiation, apoptosis, and tissue repair. The Galectin-7 protein belongs to the galectin family, which is defined by its conserved carbohydrate recognition domain (CRD) that binds beta-galactosides on glycoproteins and glycolipids. Encoded primarily by LGALS7 on chromosome 19q13.2, and to a lesser extent by LGALS7B (a highly similar duplicate), Galectin-7 acts as both an intracellular modulator of cell survival and an extracellular signaling molecule influencing cell adhesion and immune response.\u003cbr\u003e\u003cbr\u003eGalectin-7 is expressed abundantly in stratified epithelia, including the skin, cornea, and mucosal linings. It plays an important role in maintaining epithelial homeostasis by regulating keratinocyte differentiation and apoptosis. Upon tissue injury or stress, Galectin-7 is upregulated and released into the extracellular matrix, where it modulates cell-cell adhesion and migration during wound healing. It binds to extracellular glycoproteins such as integrins and laminins, mediating epithelial remodeling and cell communication. In keratinocytes, Galectin-7 localization shifts between the cytoplasm and nucleus depending on differentiation and stress conditions.\u003cbr\u003e\u003cbr\u003eAt the cellular level, Galectin-7 interacts with intracellular proteins such as Bcl-2, promoting mitochondrial apoptosis under proapoptotic stimuli. It also influences p53-dependent transcriptional regulation of cell death genes. Through these pathways, Galectin-7 acts as a proapoptotic factor in damaged epithelial cells while promoting tissue regeneration. Overexpression of Galectin-7 enhances apoptosis and accelerates wound closure, whereas its loss impairs epithelial renewal and barrier integrity.\u003cbr\u003e\u003cbr\u003eThe LGALS7\/7B antibody is widely used in epithelial biology, dermatology, and oncology research to study differentiation, apoptosis, and cell adhesion. Western blot analysis identifies a 15 kilodalton band corresponding to Galectin-7, and immunohistochemistry reveals strong cytoplasmic and nuclear staining in epithelial layers. This antibody enables analysis of Galectin-7 distribution in normal and neoplastic tissues, supporting studies of epithelial morphogenesis and repair.\u003cbr\u003e\u003cbr\u003eIn cancer, Galectin-7 shows context-dependent functions—it can suppress tumor progression in certain epithelial cancers by promoting apoptosis but can also enhance metastasis in others by regulating cell migration and extracellular matrix interactions. Altered expression has been reported in breast, cervical, and gastric cancers. The LGALS7\/7B antibody is a critical reagent for understanding how glycan-binding proteins contribute to cancer cell plasticity, metastasis, and immune regulation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=7B - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=7B - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=7B - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/7B - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=7B+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047299801453,"sku":"FY12768","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_6034f3ee-b630-47ba-9eea-025ac7154cd7.jpg?v=1782237035","url":"https:\/\/www.ebiohippo.com\/products\/lgals7-7b-antibody-galectin-7-bha17135671","provider":"BioHippo","version":"1.0","type":"link"}