{"product_id":"lig4-polyclonal-antibody-bha10317564","title":"LIG4 Polyclonal Antibody","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n\u003c\/style\u003e\n\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eThe protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.\u003c\/p\u003e\n\n\u003ch2\u003eValidated Applications \u0026amp; Recommended Dilutions\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003eApplication\u003c\/th\u003e\n\u003cth\u003eRecommended Dilution\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImmunohistochemistry\u003c\/td\u003e\n\u003ctd\u003eIHC 1:50-1:300\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\n\u003ch2\u003eAntibody Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003eTarget\u003c\/th\u003e\n\u003ctd\u003eLIG4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eHost Species\u003c\/th\u003e\n\u003ctd\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eClonality\u003c\/th\u003e\n\u003ctd\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eIsotype\u003c\/th\u003e\n\u003ctd\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eConjugate\u003c\/th\u003e\n\u003ctd\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurification\u003c\/th\u003e\n\u003ctd\u003eAntigen Affinity Purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eConcentration\u003c\/th\u003e\n\u003ctd\u003e1.08 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\n\u003ch2\u003eImmunogen\u003c\/h2\u003e\n\u003cp\u003eFusion protein of human LIG4 UniProt: \u003ca href=\"https:\/\/www.uniprot.org\/uniprot\/P49917\" target=\"_blank\"\u003eP49917\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eSpecies Reactivity \u0026amp; Cross-Reactivity\u003c\/h2\u003e\n\u003cp\u003eValidated for: Human, Mouse. Verify suitability in your sample type prior to use. For species or applications not listed in the datasheet, consult our technical team before purchase.\u003c\/p\u003e\n\n\u003ch2\u003eStorage \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\u003cp\u003eStore at -20℃ Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eStorage Buffer:\u003c\/strong\u003e PBS with 0.05% NaN3 and 40% Glycerol,pH7.4\u003c\/p\u003e\n\n\u003ch2\u003eRelated Products\u003c\/h2\u003e\n\u003cp\u003eBrowse additional antibodies targeting LIG4 and complementary reagents — including secondary antibodies, blocking buffers, and detection kits — available through BioHippo.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Elabscience Biotechnology Co Ltd","offers":[{"title":"20 uL","offer_id":53336491131245,"sku":"E-AB-52776_20μL","price":73.0,"currency_code":"USD","in_stock":true},{"title":"60 uL","offer_id":53336672764269,"sku":"E-AB-52776_60μL","price":143.0,"currency_code":"USD","in_stock":true},{"title":"120 uL","offer_id":53336672797037,"sku":"E-AB-52776_120μL","price":240.0,"currency_code":"USD","in_stock":true},{"title":"200 uL","offer_id":53336672829805,"sku":"E-AB-52776_200μL","price":399.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/LWfbL4.jpg?v=1778921149","url":"https:\/\/www.ebiohippo.com\/products\/lig4-polyclonal-antibody-bha10317564","provider":"BioHippo","version":"1.0","type":"link"}