{"product_id":"lingo2-antibody-leucine-rich-repeat-and-immunoglobulin-like-domain-containing-protein-2-bha17135950","title":"LINGO2 Antibody \/ Leucine-rich repeat and immunoglobulin-like domain-containing protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eLINGO2 Antibody \/ Leucine-rich repeat and immunoglobulin-like domain-containing protein 2 is a anti-LINGO2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e LINGO2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eLINGO2 antibody detects Leucine-rich repeat and immunoglobulin-like domain-containing protein 2, a transmembrane signaling protein implicated in nervous system development, axon guidance, and neuroprotection. The UniProt recommended name is Leucine-rich repeat and immunoglobulin-like domain-containing protein 2 (LINGO2). This glycoprotein is a member of the LINGO family, known for modulating axonal growth and synaptic plasticity through receptor complex formation.\u003cbr\u003e\u003cbr\u003eFunctionally, LINGO2 antibody identifies a 619-amino-acid membrane protein containing multiple leucine-rich repeats (LRRs) and an immunoglobulin-like domain. LINGO2 localizes primarily to neurons and glial cells, where it regulates axon regeneration and myelination processes. It functions as a negative regulator of neurite outgrowth and participates in receptor signaling complexes involving Nogo receptors (NgR) and co-receptors such as p75NTR and LINGO1.\u003cbr\u003e\u003cbr\u003eThe LINGO2 gene is located on chromosome 9q21.1 and encodes a protein expressed in brain regions including the cerebral cortex, cerebellum, and hippocampus. LINGO2 contributes to synaptic organization and neural circuit refinement, influencing learning and sensory processing. Beyond the central nervous system, it is expressed in the gastrointestinal tract and epithelial tissues, suggesting broader roles in cell communication and barrier integrity.\u003cbr\u003e\u003cbr\u003eGenetic studies have linked variants in LINGO2 to neurological and metabolic disorders, including essential tremor, Parkinson's disease, and obesity. These associations suggest that LINGO2 modulates neurotrophic signaling and energy regulation. Its expression pattern overlaps with key neuronal regulators involved in synaptic maintenance, highlighting its importance in neuronal homeostasis and repair.\u003cbr\u003e\u003cbr\u003eLINGO2 antibody is widely used in neurobiology, developmental biology, and receptor signaling research. It is suitable for immunohistochemistry, immunofluorescence, and western blotting to detect LINGO2 expression in neural tissues. This antibody supports studies of axon regeneration, neuronal receptor complexes, and synaptic plasticity. In translational research, LINGO2 is investigated as a potential target for neurodegenerative and metabolic diseases.\u003cbr\u003e\u003cbr\u003eStructurally, LINGO2 features an extracellular LRR domain forming a horseshoe-like solenoid shape that mediates protein-protein interactions, and a single-pass transmembrane domain anchoring it to the plasma membrane.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=LINGO2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=LINGO2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=LINGO2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/LINGO2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=LINGO2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047310582125,"sku":"FY13048","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_ae6202b7-9f61-43ac-8074-9a96b938f077.jpg?v=1782237068","url":"https:\/\/www.ebiohippo.com\/products\/lingo2-antibody-leucine-rich-repeat-and-immunoglobulin-like-domain-containing-protein-2-bha17135950","provider":"BioHippo","version":"1.0","type":"link"}