{"product_id":"linopirdine-dihydrochloride-bhb21300201","title":"Linopirdine dihydrochloride","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one dihydrochloride.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 113168-57-3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C26H23Cl2N3O.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.1-300 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e 100 mM in water. Centrifuge all product preparations before use (10000 x g for 1 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e 100 mM in water. Centrifuge all product preparations before use (10000 x g for 1 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e KCNQ K+ channels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e Linopirdine blocks KCNQ channels with an IC50 of 2.4 μM for KV7.2\/3 heteromers1.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eKCNQ2 (KV7.2) and KCNQ3 (KV7.3) are voltage-gated K+ channel subunits that underlie the neuronal M current1. Linopirdine, a putative cognition enhancing drug, increases acetylcholine (ACh) release in rat brain tissue and improves performance in animal models of learning and memory. In addition to ACh, Linopirdine has been shown to enhance the in vitro release of dopamine and 5-hydroxytryptamine (5-HT), and, to a lesser extent, γ-aminobutyric acid and glutamate2. The enhanced release of one or more neurotransmitters may account for the activity linopirdine displays in behavioral models of learning and memory3. The mechanism whereby linopirdine enhances acetylcholine release has been proposed to involve inhibition of the M-type K+ current (IM). Linopirdine is selective for IM with an IC50 value of 2.4 μM2.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249709834605,"sku":"L-156-10MG-1","price":229.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311562940781,"sku":"L-156-25MG-1","price":537.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311562973549,"sku":"L-156-5MG-1","price":132.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311563006317,"sku":"L-156-50MG-1","price":1036.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/L-156_gr.gif?v=1778544434","url":"https:\/\/www.ebiohippo.com\/products\/linopirdine-dihydrochloride-bhb21300201","provider":"BioHippo","version":"1.0","type":"link"}