{"product_id":"lix1l-antibody-limb-and-cns-expressed-protein-1-like-bha17135615","title":"LIX1L Antibody \/ Limb and CNS expressed protein 1-like","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eLIX1L Antibody \/ Limb and CNS expressed protein 1-like is a anti-LIX1L Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as ELISA, Flow cytometry (FACS), Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e LIX1L\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e ELISA, FACS, WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eLIX1L antibody detects Limb and CNS expressed protein 1-like, a cytoplasmic protein implicated in cytoskeletal regulation, cell differentiation, and organ development. Encoded by the LIX1L gene on chromosome 1p36.22, this protein shares homology with LIX1, a factor involved in limb patterning and neural morphogenesis. LIX1L contains predicted coiled-coil regions and a C-terminal domain believed to mediate protein-protein interactions important for actin organization and cellular polarity. Although its precise molecular function remains under study, LIX1L is thought to regulate cytoskeletal remodeling and epithelial-to-mesenchymal transitions during development and wound healing.\u003cbr\u003e\u003cbr\u003eLIX1L is expressed in several tissues, including the brain, liver, lung, and kidney, with enriched expression in mesenchymal and epithelial cell types. Studies suggest that LIX1L contributes to cell motility by influencing actin filament organization and adhesion dynamics. In hepatic tissue, it may participate in regeneration and fibrotic remodeling, while in the nervous system it supports neuronal morphogenesis. The protein is also expressed during embryogenesis, where it may cooperate with LIM-homeodomain transcription factors to guide organogenesis. Dysregulated expression of LIX1L has been associated with certain cancers, including hepatocellular carcinoma and glioma, where it correlates with invasive behavior and poor prognosis.\u003cbr\u003e\u003cbr\u003eThe LIX1L antibody is useful in developmental, cancer, and cytoskeletal research. Western blot analysis reveals a 35 kilodalton band corresponding to the full-length protein, and immunofluorescence shows cytoplasmic staining that co-localizes with filamentous actin structures. In cell migration assays, modulation of LIX1L levels alters lamellipodia formation and motility, highlighting its cytoskeletal role. Researchers use the LIX1L antibody to characterize its distribution across tissues and to evaluate its potential as a biomarker of epithelial plasticity.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=LIX1L - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=LIX1L - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=LIX1L - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/LIX1L - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=LIX1L+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047297573229,"sku":"FY12712","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_bee1238e-5cc6-437e-9c5e-000bd87f6286.jpg?v=1782237034","url":"https:\/\/www.ebiohippo.com\/products\/lix1l-antibody-limb-and-cns-expressed-protein-1-like-bha17135615","provider":"BioHippo","version":"1.0","type":"link"}