{"product_id":"lmntd1-antibody-lamin-tail-domain-containing-protein-1-bha17135463","title":"LMNTD1 Antibody \/ Lamin tail domain-containing protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eLMNTD1 Antibody \/ Lamin tail domain-containing protein 1 is a anti-LMNTD1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e LMNTD1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eLMNTD1 antibody detects Lamin tail domain-containing protein 1, a poorly characterized nuclear envelope-associated protein believed to play roles in chromatin organization, nuclear structure, and cell differentiation. LMNTD1 is part of the broader family of lamin-associated proteins that contribute to the mechanical stability and spatial arrangement of the nucleus. The LMNTD1 antibody is used in studies of nuclear architecture, gene expression control, and tissue-specific nuclear envelope composition.\u003cbr\u003e\u003cbr\u003eLMNTD1 is encoded by the LMNTD1 gene located on human chromosome 8p21.3. The protein is approximately 63 kilodaltons and characterized by a conserved lamin tail domain that mediates binding to lamins A\/C and chromatin-associated factors. LMNTD1 localizes to the inner nuclear membrane, where it may anchor chromatin regions and participate in gene silencing through lamina-associated domains (LADs).\u003cbr\u003e\u003cbr\u003eThe LMNTD1 antibody detects a 63 kilodalton band in western blot analysis and shows nuclear rim staining under confocal microscopy. Although its function remains incompletely defined, LMNTD1 is proposed to stabilize nuclear structure during differentiation and respond to mechanical stress transmitted through the cytoskeleton. Expression studies indicate enrichment in testis, brain, and embryonic tissues, suggesting developmental and reproductive roles.\u003cbr\u003e\u003cbr\u003eEmerging data suggest LMNTD1 interacts with components of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, potentially influencing nuclear positioning and signal transduction. Altered LMNTD1 expression has been observed in certain cancers and developmental disorders, where disrupted nuclear architecture correlates with genomic instability and transcriptional dysregulation.\u003cbr\u003e\u003cbr\u003eBy linking nuclear lamina integrity with chromatin organization, LMNTD1 contributes to structural and functional compartmentalization of the nucleus.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=LMNTD1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=LMNTD1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=LMNTD1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/LMNTD1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=LMNTD1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047292428653,"sku":"FY12560","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_7a6ae104-98c5-4880-bd25-6dfba5a5bdc8.jpg?v=1782237014","url":"https:\/\/www.ebiohippo.com\/products\/lmntd1-antibody-lamin-tail-domain-containing-protein-1-bha17135463","provider":"BioHippo","version":"1.0","type":"link"}