{"product_id":"lpar5-antibody-lysophosphatidic-acid-receptor-5-bha17136086","title":"LPAR5 Antibody \/ Lysophosphatidic acid receptor 5","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eLPAR5 Antibody \/ Lysophosphatidic acid receptor 5 is a anti-LPAR5 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e LPAR5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eLPAR5 antibody detects Lysophosphatidic acid receptor 5, a G protein-coupled receptor (GPCR) that mediates signaling by lysophosphatidic acid (LPA), a bioactive phospholipid involved in cell proliferation, motility, and immune regulation. The UniProt recommended name is Lysophosphatidic acid receptor 5 (LPAR5). This receptor couples primarily to G12\/13 and Gq proteins, triggering downstream activation of Rho and phospholipase C pathways.\u003cbr\u003e\u003cbr\u003eFunctionally, LPAR5 antibody identifies a 353-amino-acid receptor localized to the plasma membrane. LPAR5 activation induces calcium mobilization, cytoskeletal rearrangement, and cytokine release. It contributes to pain sensation, vascular permeability, and immune cell migration. In neuronal cells, LPAR5 influences axonal guidance and neuroinflammation.\u003cbr\u003e\u003cbr\u003eThe LPAR5 gene is located on chromosome 12p13.31 and is expressed in platelets, lymphocytes, dorsal root ganglia, and intestinal epithelial cells. It plays roles in both physiological and pathological processes such as wound healing, sensory transmission, and inflammation.\u003cbr\u003e\u003cbr\u003ePathologically, dysregulation of LPAR5 signaling has been implicated in neuropathic pain, cancer metastasis, and autoimmune diseases. Inhibition of LPAR5 reduces pain hypersensitivity and inflammatory cytokine production, making it a potential therapeutic target. Research using LPAR5 antibody supports studies in GPCR signaling, lipid biology, and inflammation.\u003cbr\u003e\u003cbr\u003eLPAR5 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect LPA receptors. \u003cbr\u003e\u003cbr\u003eStructurally, Lysophosphatidic acid receptor 5 contains seven transmembrane helices and intracellular loops that couple to G proteins and scaffolding proteins. This antibody facilitates exploration of LPAR5's signaling mechanisms and receptor-mediated physiological responses.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=LPAR5 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=LPAR5 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=LPAR5 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/LPAR5 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=LPAR5+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047318151533,"sku":"FY13184","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_6d5aff81-24d1-42a7-a221-494e840b3c17.jpg?v=1782237083","url":"https:\/\/www.ebiohippo.com\/products\/lpar5-antibody-lysophosphatidic-acid-receptor-5-bha17136086","provider":"BioHippo","version":"1.0","type":"link"}