{"product_id":"lrg1-antibody-leucine-rich-alpha-2-glycoprotein-1-bha17136034","title":"LRG1 Antibody \/ Leucine-rich alpha-2-glycoprotein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eLRG1 Antibody \/ Leucine-rich alpha-2-glycoprotein 1 is a anti-LRG1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e LRG1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eLRG1 antibody detects Leucine-rich alpha-2-glycoprotein 1, a secreted glycoprotein that regulates angiogenesis, inflammation, and tissue remodeling. The UniProt recommended name is Leucine-rich alpha-2-glycoprotein 1 (LRG1). This plasma protein belongs to the leucine-rich repeat (LRR) family and interacts with transforming growth factor-beta (TGF-beta) signaling pathways to influence vascular and immune responses.\u003cbr\u003e\u003cbr\u003eFunctionally, LRG1 antibody identifies a 312-amino-acid glycoprotein composed of eight leucine-rich repeats forming a curved solenoid structure. LRG1 modulates endothelial cell behavior by binding endoglin and shifting TGF-beta signaling from the ALK5\/SMAD2\/3 axis to the ALK1\/SMAD1\/5\/8 pathway, promoting angiogenesis. It also serves as an acute-phase reactant, increasing during infection, inflammation, and tissue injury.\u003cbr\u003e\u003cbr\u003eThe LRG1 gene is located on chromosome 19p13.3 and is highly expressed in liver, endothelial cells, and neutrophils. LRG1 is secreted into plasma, cerebrospinal fluid, and extracellular matrix, where it influences cell adhesion, migration, and vascular remodeling. Elevated serum LRG1 is a biomarker of cardiovascular and inflammatory diseases.\u003cbr\u003e\u003cbr\u003ePathologically, dysregulation of LRG1 contributes to diabetic retinopathy, fibrosis, tumor angiogenesis, and inflammatory disorders. Overexpression of LRG1 promotes abnormal vessel formation and tissue remodeling, while inhibition can suppress pathological angiogenesis. Research using LRG1 antibody supports studies in vascular biology, immunology, and biomarker discovery.\u003cbr\u003e\u003cbr\u003eLRG1 antibody is validated for ELISA, western blotting, and immunohistochemistry to detect secreted and tissue-associated glycoproteins. \u003cbr\u003e\u003cbr\u003eStructurally, Leucine-rich alpha-2-glycoprotein 1 adopts a horseshoe-shaped LRR domain that mediates protein-protein interactions with growth factors and receptors. This antibody enables investigation of LRG1's role in vascular signaling and disease progression.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=LRG1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=LRG1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=LRG1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/LRG1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=LRG1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047312777581,"sku":"FY13132","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f290751e-a84e-4cff-b5ec-390ec3deaf55.jpg?v=1782237113","url":"https:\/\/www.ebiohippo.com\/products\/lrg1-antibody-leucine-rich-alpha-2-glycoprotein-1-bha17136034","provider":"BioHippo","version":"1.0","type":"link"}