{"product_id":"lrrc71-antibody-leucine-rich-repeat-containing-protein-71-bha17135391","title":"LRRC71 Antibody \/ Leucine-rich repeat-containing protein 71","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eLRRC71 Antibody \/ Leucine-rich repeat-containing protein 71 is a anti-LRRC71 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e LRRC71\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eLRRC71 antibody detects Leucine-rich repeat-containing protein 71, a cytoplasmic and possibly nuclear protein characterized by multiple leucine-rich repeat motifs involved in protein-protein interactions. While the precise biological function of LRRC71 is still being elucidated, members of the leucine-rich repeat (LRR) family are commonly associated with cellular signaling, adhesion, and developmental regulation. The LRRC71 antibody is used in studies examining protein interaction networks, signal transduction pathways, and the potential roles of LRR proteins in neuronal and reproductive biology.\u003cbr\u003e\u003cbr\u003eLRRC71 is encoded by the LRRC71 gene located on human chromosome 8q24.3. The protein contains tandem LRR motifs forming a horseshoe-shaped structure that facilitates binding to various partners, including receptors, kinases, and cytoskeletal proteins. Bioinformatic analyses suggest roles in cell differentiation and communication, possibly through modulation of receptor signaling. Expression profiling has revealed LRRC71 mRNA in multiple tissues, with enrichment in testis, brain, and epithelial organs, indicating possible participation in spermatogenesis and neurodevelopment.\u003cbr\u003e\u003cbr\u003eUsing the LRRC71 antibody, researchers can detect a band between 60-70 kilodaltons on western blot, corresponding to the predicted molecular weight of the protein. Immunostaining studies show cytoplasmic and perinuclear localization, consistent with a signaling or adaptor function. Although direct physiological functions remain under active investigation, related LRR family members are known to mediate receptor clustering and intracellular scaffolding, suggesting a conserved molecular role for LRRC71 in signal integration and cell organization.\u003cbr\u003e\u003cbr\u003eEmerging data suggest LRRC71 may interact with intracellular components regulating calcium signaling or vesicular trafficking. Its predicted structural features imply involvement in membrane-proximal signaling complexes that respond to developmental or stress cues. Further investigation may also link LRRC71 to fertility regulation, as several LRR proteins participate in germ cell communication and acrosome formation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=LRRC71 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=LRRC71 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=LRRC71 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/LRRC71 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=LRRC71+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047289872749,"sku":"FY12488","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d9870ee4-5dd8-44f7-8d22-45b11d88a254.jpg?v=1782237014","url":"https:\/\/www.ebiohippo.com\/products\/lrrc71-antibody-leucine-rich-repeat-containing-protein-71-bha17135391","provider":"BioHippo","version":"1.0","type":"link"}