{"product_id":"lsp1-antibody-lymphocyte-specific-protein-1-bha17135664","title":"LSP1 Antibody \/ Lymphocyte-specific protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eLSP1 Antibody \/ Lymphocyte-specific protein 1 is a anti-LSP1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e LSP1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eLSP1 antibody detects Lymphocyte-specific protein 1, an F-actin binding protein that regulates cytoskeletal remodeling, leukocyte motility, and endothelial cell migration. Encoded by the LSP1 gene on chromosome 11p15.5, this protein is expressed in leukocytes, endothelial cells, and dendritic cells. LSP1 localizes to the cytoplasmic side of the plasma membrane and associates with actin filaments to coordinate cell adhesion and migration in response to inflammatory or chemotactic signals. It is phosphorylated by protein kinase C and MAP kinases, which regulate its subcellular distribution and cytoskeletal interactions.\u003cbr\u003e\u003cbr\u003eLSP1 modulates actin cytoskeleton dynamics by linking signaling pathways to filament organization. It participates in neutrophil chemotaxis, macrophage spreading, and lymphocyte trafficking through integrin and chemokine receptor signaling. In endothelial cells, LSP1 promotes actin rearrangement necessary for wound closure and angiogenic migration. It also regulates the stability of cell-cell junctions during inflammation, contributing to vascular permeability control.\u003cbr\u003e\u003cbr\u003eThe LSP1 antibody is widely used in immunology, vascular biology, and cytoskeletal research to detect Lymphocyte-specific protein 1 expression and function. Western blot analysis identifies a 60 kilodalton band corresponding to LSP1, while immunofluorescence demonstrates filamentous cytoplasmic staining that colocalizes with actin. In immune tissues, LSP1 staining highlights lymphocytes, macrophages, and endothelial cells at sites of inflammation, making it a valuable marker of cell motility and immune activation.\u003cbr\u003e\u003cbr\u003eAberrant expression or phosphorylation of LSP1 has been linked to chronic inflammatory diseases, autoimmune disorders, and tumor metastasis. It functions as a regulator of leukocyte extravasation and tissue infiltration. The LSP1 antibody supports studies of cytoskeletal regulation, immune cell dynamics, and endothelial remodeling.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=LSP1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=LSP1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=LSP1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/LSP1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=LSP1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047299441005,"sku":"FY12761","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_e05d0fe9-3363-4a58-a84a-76637e2b5613.jpg?v=1782237037","url":"https:\/\/www.ebiohippo.com\/products\/lsp1-antibody-lymphocyte-specific-protein-1-bha17135664","provider":"BioHippo","version":"1.0","type":"link"}