{"product_id":"ltbr-antibody-lymphotoxin-beta-receptor-bha17136123","title":"LTBR Antibody \/ Lymphotoxin-beta receptor","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eLTBR Antibody \/ Lymphotoxin-beta receptor is a anti-LTBR Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e LTBR\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eLTBR antibody detects Lymphotoxin-beta receptor, a cell surface receptor belonging to the tumor necrosis factor receptor (TNFR) superfamily that mediates immune signaling, inflammation, and lymphoid tissue organization. The UniProt recommended name is Lymphotoxin-beta receptor (LTBR). This receptor binds the lymphotoxin-alpha1\/beta2 heterotrimer and LIGHT (TNFSF14), activating downstream pathways that regulate immune homeostasis and cell survival.\u003cbr\u003e\u003cbr\u003eFunctionally, LTBR antibody identifies a 435-amino-acid type I transmembrane receptor expressed on epithelial cells, stromal cells, and endothelial cells but absent from most hematopoietic cells. Upon ligand binding, LTBR triggers activation of NF-kappaB, JNK, and MAPK signaling pathways, leading to expression of cytokines, chemokines, and adhesion molecules. These signals promote lymphoid organogenesis, maintenance of high endothelial venules, and antiviral defense. LTBR signaling also induces controlled apoptosis during immune regulation and tissue remodeling.\u003cbr\u003e\u003cbr\u003eThe LTBR gene is located on chromosome 12p13.31 and is expressed in lymphoid tissues, intestinal epithelium, and vascular endothelium. It plays a central role in secondary lymphoid organ development, including the formation of lymph nodes and Peyer�s patches, as well as in maintaining immune compartmentalization within mucosal barriers.\u003cbr\u003e\u003cbr\u003ePathologically, dysregulation of LTBR contributes to autoimmune diseases, chronic inflammation, and tumor immunity. Hyperactivation promotes lymphoid neogenesis and ectopic germinal center formation in autoimmune conditions such as rheumatoid arthritis and multiple sclerosis, whereas impaired signaling weakens antiviral responses. In cancer, LTBR signaling can either promote tumor cell survival or enhance immune-mediated tumor clearance depending on context. Research using LTBR antibody supports studies in immunology, inflammation, and cancer biology.\u003cbr\u003e\u003cbr\u003eLTBR antibody is validated for flow cytometry, western blotting, and immunohistochemistry to detect TNF receptor family proteins. \u003cbr\u003e\u003cbr\u003eStructurally, Lymphotoxin-beta receptor contains four extracellular cysteine-rich domains for ligand binding and a cytoplasmic tail with TRAF-binding motifs that mediate signal transduction. Its modular design allows recruitment of adaptor proteins that determine specific pathway activation. This antibody facilitates detailed analysis of LTBR's roles in cytokine signaling, immune structure formation, and tissue homeostasis.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=LTBR - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=LTBR - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=LTBR - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/LTBR - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=LTBR+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047318774125,"sku":"FY13221","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_0d478da5-5132-4192-b8d5-6b4e52235e49.jpg?v=1782237078","url":"https:\/\/www.ebiohippo.com\/products\/ltbr-antibody-lymphotoxin-beta-receptor-bha17136123","provider":"BioHippo","version":"1.0","type":"link"}