{"product_id":"lunularin-bhb21900612","title":"Lunularin","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}.bhp-desc p{margin:0 0 12px}.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\u003c\/style\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003eEndogenous Metabolites\u003c\/span\u003e\u003ch2\u003eCompound Overview\u003c\/h2\u003e\n\u003cp\u003eLunularin inhibits 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), with an IC\u003csub\u003e50\u003c\/sub\u003e of 45.44 μM and a K\u003csub\u003ei\u003c\/sub\u003e of 35.8 μM against the human enzyme, and an IC\u003csub\u003e50\u003c\/sub\u003e of 17.39 μM and a K\u003csub\u003ei\u003c\/sub\u003e of 10.31 μM against the rat enzyme. It upregulates hepatic Sirt1 and Hmox1 transcription, reduces food intake and body weight gain, and lowers blood glucose in mice fed a high-fat diet, while also inhibiting LPS-induced TLR4-mediated NF-κB activation and nitric oxide production. It inhibits proliferation and colony formation of renal and colon cancer cells with cancer cell-specific cytotoxicity, and binds the steroid-binding site of human 11β-HSD1 and the steroid\/NADPH-binding region of rat 11β-HSD1, without inhibiting 11β-HSD2 or mouse 11β-HSD1; it can be used in research on diet-induced obesity, renal and colorectal cancer, inflammatory disease and metabolic syndrome\u003csup\u003e[1][2][3][4]\u003c\/sup\u003e. It is supplied as a white to off-white solid (C14H14O2, MW 214.26) at 99.87% purity and occurs naturally in the plant Conocephalum conicum (L.) Dumort. and as a human gut microbiota metabolite.\u003c\/p\u003e\n\u003ch2\u003ePhysical \u0026amp; Chemical Properties\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e37116-80-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eC14H14O2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e214.26 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e99.87%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eAppearance\u003c\/th\u003e\n\u003ctd\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eColor\u003c\/th\u003e\n\u003ctd\u003eWhite to off-white\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStructure Classification\u003c\/th\u003e\n\u003ctd\u003ePhenols Polyphenols\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd\u003eOC1=CC=C(CCC2=CC=CC(O)=C2)C=C1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSignaling Pathway\u003c\/th\u003e\n\u003ctd\u003eMetabolic Enzyme\/Protease\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eInitial Source\u003c\/th\u003e\n\u003ctd\u003ePlant — Conocephalum conicum (L.) Dumort.; Endogenous metabolite — Human Gut Microbiota Metabolites\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSolubility\u003c\/th\u003e\n\u003ctd\u003eIn Vitro: DMSO: 100 mg\/mL (466.72 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003e4°C, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (stored under nitrogen).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom temperature in continental US; may vary elsewhere.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003ch2\u003eLiterature Cited\u003c\/h2\u003e\n\u003cp style=\"font-size:14px;color:#555;margin:0 0 10px\"\u003e\u003cem\u003eSources cited in this description and in the In Vitro \u0026amp; In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e [1]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30872769\"\u003ePallauf K, et al. Resveratrol, lunularin and dihydroresveratrol do not act as caloric restriction mimetics when administered intraperitoneally in mice. Sci Rep. 2019;9(1):4445. Published 2019 Mar 14.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e [2]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35634412\"\u003eLi F, et al. Gut Microbiota-Derived Resveratrol Metabolites, Dihydroresveratrol and Lunularin, Significantly Contribute to the Biological Activities of Resveratrol. Front Nutr. 2022;9:912591. Published 2022 May 11.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e [3]. Suire C, et al. Chirality of terpenoids isolated from the liverwort Conocephalum Conicum[J]. Phytochemistry, 1982, 21(2): 349-352.\u003c\/p\u003e\n\u003cp\u003e [4]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39139138\"\u003eHu C, et al. Resveratrol analogues and metabolites selectively inhibit human and rat 11β-hydroxysteroid dehydrogenase 1 as the therapeutic drugs: structure-activity relationship and molecular dynamics analysis. SAR QSAR Environ Res. 2024;35(7):641-663.\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003eSafety\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\u003cp\u003e\u003cstrong\u003eFor Research Use Only.\u003c\/strong\u003e Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.\u003c\/p\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"MedChemExpress (MCE)","offers":[{"title":"100 mg","offer_id":67604874232173,"sku":"HY-124529-100MG","price":84.0,"currency_code":"USD","in_stock":true},{"title":"250 mg","offer_id":67605111865709,"sku":"HY-124529-250MG","price":180.0,"currency_code":"USD","in_stock":true},{"title":"500 mg","offer_id":67605111898477,"sku":"HY-124529-500MG","price":306.0,"currency_code":"USD","in_stock":true},{"title":"1 g","offer_id":67605111931245,"sku":"HY-124529-1G","price":522.0,"currency_code":"USD","in_stock":true},{"title":"5 g","offer_id":67605111964013,"sku":"HY-124529-5G","price":0.0,"currency_code":"USD","in_stock":true},{"title":"10 g","offer_id":67605111996781,"sku":"HY-124529-10G","price":0.0,"currency_code":"USD","in_stock":true},{"title":"1 mL x 10 mM (in DMSO)","offer_id":67605112029549,"sku":"HY-124529-1MLX10MM","price":93.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hy-124529.gif?v=1790972917","url":"https:\/\/www.ebiohippo.com\/products\/lunularin-bhb21900612","provider":"BioHippo","version":"1.0","type":"link"}