{"product_id":"lyn-antibody-tyrosine-protein-kinase-lyn-bha17136277","title":"LYN Antibody \/ Tyrosine-protein kinase Lyn","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eLYN Antibody \/ Tyrosine-protein kinase Lyn is a anti-LYN Rabbit antibody Recombinant Rabbit Monoclonal clone 32L39 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e LYN\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32L39, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eLYN antibody detects Tyrosine-protein kinase Lyn, encoded by the LYN gene. Tyrosine-protein kinase Lyn is a member of the Src family of non-receptor tyrosine kinases and is widely expressed in hematopoietic cells, where it plays essential roles in immune receptor signaling, proliferation, differentiation, and apoptosis. LYN antibody provides researchers with a specific reagent for studying signaling networks that govern immune cell activation and cancer biology.\u003cbr\u003e\u003cbr\u003eTyrosine-protein kinase Lyn functions downstream of antigen and cytokine receptors, phosphorylating immunoreceptor tyrosine-based activation and inhibition motifs. Research using LYN antibody has shown that it can both activate and inhibit signaling depending on context, making it a key modulator of immune responses. Lyn phosphorylates substrates such as SYK, PI3K, and SHP phosphatases, coordinating positive and negative feedback loops. This dual regulatory role highlights its importance in immune tolerance and activation balance.\u003cbr\u003e\u003cbr\u003eStudies with LYN antibody have revealed its role in B cell receptor signaling. Tyrosine-protein kinase Lyn initiates signaling by phosphorylating immunoreceptor tyrosine-based activation motifs, recruiting downstream effectors that drive calcium flux, gene transcription, and survival. At the same time, it phosphorylates inhibitory motifs that recruit phosphatases to limit signaling intensity. This balance prevents inappropriate activation while allowing robust responses to pathogens.\u003cbr\u003e\u003cbr\u003eDysregulation of Lyn contributes to disease. Research using LYN antibody has demonstrated that overactive Lyn signaling is implicated in chronic myeloid leukemia and B cell malignancies, where it enhances survival and proliferation. Conversely, deficiency or loss of Lyn function contributes to autoimmune disorders by impairing inhibitory signaling. These findings establish Lyn as a therapeutic target in both cancer and autoimmunity.\u003cbr\u003e\u003cbr\u003eLyn also participates in platelet activation, mast cell degranulation, and macrophage responses, emphasizing its broad roles in hematopoietic physiology. Beyond immune function, Lyn contributes to epithelial and neuronal signaling, expanding its relevance to non-hematopoietic systems. These functions highlight the versatility of Tyrosine-protein kinase Lyn as a signaling hub.\u003cbr\u003e\u003cbr\u003eLYN antibody is widely used in western blotting, immunohistochemistry, and immunoprecipitation. Western blotting detects total protein levels and phosphorylation states, immunohistochemistry reveals expression in lymphoid organs, and immunoprecipitation enables mapping of protein complexes. These applications make LYN antibody essential for signaling research.\u003cbr\u003e\u003cbr\u003eBy supplying validated LYN antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=LYN - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=LYN - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=LYN - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/LYN - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=LYN+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047324148077,"sku":"FY13375","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_88aa422f-5e58-40c6-bb0d-5a106183f5cd.jpg?v=1772019435","url":"https:\/\/www.ebiohippo.com\/products\/lyn-antibody-tyrosine-protein-kinase-lyn-bha17136277","provider":"BioHippo","version":"1.0","type":"link"}