{"product_id":"lyrm4-antibody-lyr-motif-containing-protein-4-bha17135521","title":"LYRM4 Antibody \/ LYR motif-containing protein 4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eLYRM4 Antibody \/ LYR motif-containing protein 4 is a anti-LYRM4 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e LYRM4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eLYRM4 antibody detects LYR motif-containing protein 4, a mitochondrial scaffold protein essential for assembly of the iron-sulfur (Fe-S) cluster synthesis complex. LYRM4 plays a central role in mitochondrial energy metabolism by stabilizing the cysteine desulfurase NFS1 and facilitating delivery of sulfur to Fe-S cluster acceptor proteins. The LYRM4 antibody is widely used in mitochondrial biology and bioenergetics research to study iron-sulfur assembly, oxidative phosphorylation, and metabolic regulation.\u003cbr\u003e\u003cbr\u003eLYRM4 is encoded by the LYRM4 gene located on human chromosome 6p25.1. The protein is approximately 108 amino acids long and contains a conserved LYR motif (Leucine-Tyrosine-Arginine) that mediates protein-protein interactions within mitochondrial assembly complexes. LYRM4 localizes to the mitochondrial matrix, where it forms a complex with NFS1, ISD11, and ACP (acyl carrier protein) to generate Fe-S clusters required for electron transport chain enzymes and metabolic enzymes such as aconitase and succinate dehydrogenase.\u003cbr\u003e\u003cbr\u003eThe LYRM4 antibody detects a 12 kilodalton band by western blot and shows mitochondrial matrix localization under immunofluorescence. LYRM4 is indispensable for mitochondrial biogenesis and redox balance. Its loss leads to impaired respiratory chain function, reduced ATP generation, and increased oxidative stress. Inherited mutations in LYRM4 cause mitochondrial disorders characterized by lactic acidosis, muscle weakness, and neurodegeneration.\u003cbr\u003e\u003cbr\u003eBeyond its structural role in Fe-S cluster biogenesis, LYRM4 participates in metabolic adaptation under hypoxia and nutrient deprivation, regulating Fe-S cluster allocation between metabolic enzymes. It also influences lipoic acid synthesis and coenzyme Q biosynthesis through shared pathways in mitochondrial metabolism. Dysregulation of LYRM4 has been associated with oxidative damage and mitochondrial DNA instability in various pathologies, including Parkinson's disease and metabolic syndrome.\u003cbr\u003e\u003cbr\u003eBecause LYRM4 integrates iron-sulfur metabolism with mitochondrial energy production, it serves as a fundamental component of cellular respiration and redox regulation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=LYRM4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=LYRM4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=LYRM4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/LYRM4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=LYRM4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047294230893,"sku":"FY12618","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_99be3762-9fa3-464f-9b84-f6c44006074e.jpg?v=1782237029","url":"https:\/\/www.ebiohippo.com\/products\/lyrm4-antibody-lyr-motif-containing-protein-4-bha17135521","provider":"BioHippo","version":"1.0","type":"link"}