{"product_id":"lzts2-antibody-leucine-zipper-putative-tumor-suppressor-2-bha17135312","title":"LZTS2 Antibody \/ Leucine zipper putative tumor suppressor 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eLZTS2 Antibody \/ Leucine zipper putative tumor suppressor 2 is a anti-LZTS2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e LZTS2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe LZTS2 antibody targets Leucine zipper putative tumor suppressor 2, a microtubule-associated protein encoded by the LZTS2 gene. Leucine zipper putative tumor suppressor 2 acts as a cell cycle regulator and transcriptional modulator involved in mitosis, cytoskeletal organization, and growth control. It functions as a negative regulator of beta-catenin signaling and participates in centrosome integrity and spindle orientation. The LZTS2 antibody provides a key tool for studying tumor suppression, cytoskeletal regulation, and Wnt signaling dynamics.\u003cbr\u003e\u003cbr\u003eLeucine zipper putative tumor suppressor 2 contains multiple coiled-coil and leucine zipper motifs that facilitate protein-protein interactions and localization to microtubules and centrosomes. During mitosis, it associates with the spindle apparatus and contributes to chromosome segregation fidelity. The LZTS2 antibody supports localization studies that reveal its role in maintaining mitotic stability and preventing aneuploidy. Loss of LZTS2 disrupts spindle organization and cell division, leading to chromosomal instability that can promote tumorigenesis.\u003cbr\u003e\u003cbr\u003eAs a regulator of Wnt\/beta-catenin signaling, Leucine zipper putative tumor suppressor 2 binds beta-catenin and inhibits its nuclear translocation, thereby attenuating transcription of Wnt target genes involved in proliferation. The LZTS2 antibody enables detection of expression changes in response to Wnt pathway activation or tumor progression. Reduced levels of LZTS2 have been documented in prostate, colorectal, and lung cancers, correlating with enhanced beta-catenin activity and increased malignancy.\u003cbr\u003e\u003cbr\u003eBeyond cancer biology, Leucine zipper putative tumor suppressor 2 contributes to neural development and cytoskeletal regulation in neurons. It stabilizes microtubule structures and promotes axonal outgrowth, suggesting functions in cellular differentiation and morphogenesis. The LZTS2 antibody supports studies into these roles, providing a means to evaluate expression across developing tissues and in response to neurotrophic factors.\u003cbr\u003e\u003cbr\u003eThe LZTS2 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, producing characteristic cytoplasmic and perinuclear staining consistent with microtubule association.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=LZTS2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=LZTS2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=LZTS2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/LZTS2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=LZTS2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047286333805,"sku":"FY12409","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_eb510d97-03b2-4e04-8200-9147ea55025a.jpg?v=1782236990","url":"https:\/\/www.ebiohippo.com\/products\/lzts2-antibody-leucine-zipper-putative-tumor-suppressor-2-bha17135312","provider":"BioHippo","version":"1.0","type":"link"}