{"product_id":"m8-b-hydrochloride-bhb21300222","title":"M8-B hydrochloride","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e N-(2-aminoethyl)-N-[(3-methoxy-4 phenylmethoxyphenyl) methyl]thiophene-2 carboxamide;hydrochloride.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 883976-12-3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C22H25ClN2O3S.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 10 nM - 10 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TRPM8 channel\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e M8-B hydrochloride is a potent and selective blocker of TRPM8 channel, inhibiting rat and human TRPM8 activation by cold, by icilin and by menthol with IC50 values of 7.8 nM, 26.9 nM and 64.3 nM, respectively, whilst having little or no effect on other TRP channels (IC50 \u0026gt; 20 μM)1.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eM8-B hydrochloride is a potent and selective antagonist of the transient receptor potential melastatin-8 (TRPM8) channel1. It inhibits rat and human TRPM8 channels by cold, by icilin and by menthol and demonstrates IC50 values of 7.8 nM, 26.9 nM, and 64.3 nM, respectively. The compound shows little or no effect on other TRP channels1.TRPM8 is a Ca2+-permeable channel, a member of the 'long' or melastatin (M) group of TRP channels and is activated by temperatures range of 8-28°C or by cooling compounds. The TRPM8 gene is up-regulated in prostate cancer and other malignancies. The channel is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons2,3.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249710883181,"sku":"M-220-10MG-1","price":117.0,"currency_code":"USD","in_stock":true},{"title":"100 mg \/ 1","offer_id":53311565988205,"sku":"M-220-100MG-1","price":758.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311566020973,"sku":"M-220-25MG-1","price":263.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311566053741,"sku":"M-220-5MG-1","price":85.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311566086509,"sku":"M-220-50MG-1","price":476.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/M-220_gr.gif?v=1778544435","url":"https:\/\/www.ebiohippo.com\/products\/m8-b-hydrochloride-bhb21300222","provider":"BioHippo","version":"1.0","type":"link"}