{"product_id":"magi2-antibody-membrane-associated-guanylate-kinase-inverted-2-bha17135482","title":"MAGI2 Antibody \/ Membrane-associated guanylate kinase inverted 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMAGI2 Antibody \/ Membrane-associated guanylate kinase inverted 2 is a anti-MAGI2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MAGI2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMAGI2 antibody detects Membrane-associated guanylate kinase inverted 2, a scaffolding protein located at synapses and tight junctions that organizes signaling complexes for cell polarity and neuronal function. MAGI2 belongs to the MAGUK family of adaptor proteins that coordinate receptor clustering, cytoskeletal interactions, and signal transduction. The MAGI2 antibody is used in studies of synaptic signaling, epithelial junction formation, and protein complex organization.\u003cbr\u003e\u003cbr\u003eMAGI2 is encoded by the MAGI2 gene on human chromosome 7q21.11. The protein is approximately 150 kilodaltons and composed of multiple PDZ, WW, and guanylate kinase-like domains that mediate protein-protein interactions. MAGI2 localizes to postsynaptic densities in neurons and to tight junctions in epithelial cells, where it scaffolds transmembrane receptors such as PTEN, NMDA receptor subunits, and beta-catenin.\u003cbr\u003e\u003cbr\u003e MAGI2 regulates synaptic plasticity by stabilizing glutamate receptor complexes and maintaining postsynaptic signaling strength. It also anchors PTEN to the plasma membrane, contributing to phosphoinositide signaling and tumor suppression.\u003cbr\u003e\u003cbr\u003eDefects or deletions in MAGI2 are associated with neurological disorders including autism spectrum disorder and epilepsy, as well as cancers involving disrupted cell polarity. In epithelial cells, MAGI2 supports junctional integrity and signal compartmentalization, preventing uncontrolled growth and maintaining barrier function.\u003cbr\u003e\u003cbr\u003eAs a multifunctional scaffolding protein, MAGI2 integrates membrane signaling with structural organization.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MAGI2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MAGI2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MAGI2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MAGI2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MAGI2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047292723565,"sku":"FY12579","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_8ed86edd-e529-434e-ae73-14b75eae9ef6.jpg?v=1782237032","url":"https:\/\/www.ebiohippo.com\/products\/magi2-antibody-membrane-associated-guanylate-kinase-inverted-2-bha17135482","provider":"BioHippo","version":"1.0","type":"link"}