{"product_id":"mapkapk3-antibody-mitogen-activated-protein-kinase-activated-protein-kinase-3-bha17135826","title":"MAPKAPK3 Antibody \/ Mitogen activated protein kinase activated protein kinase 3","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMAPKAPK3 Antibody \/ Mitogen activated protein kinase activated protein kinase 3 is a anti-MAPKAPK3 Rabbit antibody Recombinant Rabbit Monoclonal clone 30M15 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunoprecipitation (IP) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MAPKAPK3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30M15, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMAPKAPK3 antibody recognizes Mitogen activated protein kinase activated protein kinase 3, encoded by the MAPKAPK3 gene. This protein is a serine threonine kinase activated downstream of p38 MAP kinase and is part of a signaling cascade that regulates stress responses, transcription, and cytoskeletal organization. MAPKAPK3 antibody provides researchers with a powerful tool to study how external stimuli such as cytokines, heat shock, or ultraviolet radiation trigger intracellular signaling events that lead to adaptive changes in cell physiology. By detecting MAPKAPK3, scientists can better understand how stress activated kinases contribute to survival, inflammation, and differentiation.\u003cbr\u003e\u003cbr\u003eMitogen activated protein kinase activated protein kinase 3 phosphorylates a variety of substrates, including transcription factors, RNA binding proteins, and regulators of actin dynamics. This allows MAPKAPK3 to integrate stress signals with gene expression programs and structural remodeling. Studies with MAPKAPK3 antibody have shown that it participates in the regulation of CREB and ATF1 transcription factors, influencing expression of stress inducible genes. It also phosphorylates the small heat shock protein HSP27, altering cytoskeletal dynamics and cell motility. These diverse downstream targets highlight the broad influence of MAPKAPK3 in cellular adaptation.\u003cbr\u003e\u003cbr\u003eDysregulation of MAPKAPK3 signaling has been implicated in inflammation, cancer, and neurological disorders. Overactivation of p38 MAPK and its downstream kinases contributes to chronic inflammatory states and has been studied in conditions such as rheumatoid arthritis and inflammatory bowel disease. Research with MAPKAPK3 antibody has revealed that altered MAPKAPK3 activity can promote tumorigenesis by enhancing survival pathways and stress resistance in cancer cells. In the nervous system, MAPKAPK3 has been implicated in synaptic plasticity and memory, suggesting that disruption of its activity may contribute to cognitive impairment and neurodegeneration.\u003cbr\u003e\u003cbr\u003eMAPKAPK3 antibody is widely applied in western blotting, immunohistochemistry, and kinase assays. Western blotting detects activation and phosphorylation states, while immunohistochemistry reveals tissue specific expression patterns. Kinase assays using immunoprecipitated MAPKAPK3 protein help identify novel substrates and confirm functional activity. These approaches allow comprehensive characterization of MAPKAPK3 signaling in both health and disease.\u003cbr\u003e\u003cbr\u003eBy providing validated MAPKAPK3 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MAPKAPK3 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MAPKAPK3 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MAPKAPK3 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MAPKAPK3 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MAPKAPK3+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047306682733,"sku":"FY12924","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_a6519091-12e5-4e57-9965-2366df3e8d7b.jpg?v=1772019361","url":"https:\/\/www.ebiohippo.com\/products\/mapkapk3-antibody-mitogen-activated-protein-kinase-activated-protein-kinase-3-bha17135826","provider":"BioHippo","version":"1.0","type":"link"}