{"product_id":"matn4-antibody-matrilin-4-bha17135934","title":"MATN4 Antibody \/ Matrilin 4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMATN4 Antibody \/ Matrilin 4 is a anti-MATN4 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MATN4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMATN4 antibody detects Matrilin-4, a secreted extracellular matrix adapter protein that contributes to the structural organization of cartilage, tendon, and connective tissue matrices. The UniProt recommended name is Matrilin-4 (MATN4). This glycoprotein is a member of the matrilin family, which functions as extracellular linkers connecting collagen fibrils, proteoglycans, and other matrix molecules.\u003cbr\u003e\u003cbr\u003eFunctionally, MATN4 antibody identifies a 602-amino-acid modular protein containing von Willebrand factor A (vWFA) domains and coiled-coil motifs. MATN4 interacts with matrix components such as aggrecan, COMP, and collagens II and IX, facilitating the formation of filamentous networks that provide tensile strength and elasticity to connective tissues. It plays a structural and regulatory role in cartilage organization and tissue resilience under mechanical load.\u003cbr\u003e\u003cbr\u003eThe MATN4 gene is located on chromosome 20q13.12 and encodes a protein expressed primarily in skeletal tissues, including cartilage, intervertebral discs, and developing bone. Matrilin-4 functions as an adaptor molecule linking fibrillar collagens to proteoglycan aggregates, stabilizing the extracellular matrix architecture. During development, MATN4 expression is tightly regulated by transcription factors such as SOX9 and RUNX2 that control chondrogenesis and osteogenesis.\u003cbr\u003e\u003cbr\u003eIn physiology, MATN4 supports cartilage integrity and joint function. Reduced expression or mutations in matrilin family proteins can impair cartilage matrix stability, predisposing to osteoarthritis or connective tissue degeneration. MATN4 also contributes to tissue repair by enhancing chondrocyte adhesion and matrix assembly following injury. In cancer biology, altered MATN4 expression has been reported in breast, gastric, and pancreatic cancers, where it may influence tumor cell adhesion and invasion through modulation of the extracellular matrix microenvironment.\u003cbr\u003e\u003cbr\u003eMATN4 antibody is widely used in extracellular matrix, musculoskeletal, and developmental biology research. It is suitable for immunohistochemistry, ELISA, and western blotting to detect Matrilin-4 expression and distribution. This antibody supports studies of cartilage formation, joint pathology, and matrix protein interactions. In biomaterials research, MATN4 serves as a reference marker for cartilage scaffold design and regenerative tissue engineering.\u003cbr\u003e\u003cbr\u003eStructurally, Matrilin-4 consists of vWFA domains that mediate protein-protein binding and a coiled-coil domain enabling tetramer formation. It is secreted via the classical ER-Golgi pathway and undergoes glycosylation for structural stability.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MATN4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MATN4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MATN4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MATN4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MATN4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047309828461,"sku":"FY13032","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d35af05b-ab5b-4bdf-a572-0657b39aa257.jpg?v=1782237085","url":"https:\/\/www.ebiohippo.com\/products\/matn4-antibody-matrilin-4-bha17135934","provider":"BioHippo","version":"1.0","type":"link"}