{"product_id":"mbd2-antibody-methyl-cpg-binding-domain-protein-2-bha17128176","title":"MBD2 Antibody \/ Methyl-CpG-binding domain protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eMBD2 Antibody \/ Methyl-CpG-binding domain protein 2 is an antibody targeting \u003cstrong\u003eMBD2\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MBD2.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human, Mouse.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eMBD2 is part of a family of proteins that possess a methyl-CpG-binding domain, allowing them to recognize and bind to DNA that has been modified by the addition of methyl groups. This binding has important implications for gene expression, as methylation can either activate or repress gene transcription. One of the most intriguing aspects of MBD2 is its ability to recruit other proteins to the methylated DNA, influencing the chromatin structure and ultimately determining whether a particular gene is switched on or off. This dynamic interplay between MBD2 and other regulatory proteins highlights the complexity of epigenetic regulation. Research into MBD2 has uncovered its involvement in a wide range of biological processes, from embryonic development to cancer progression. Dysregulation of MBD2 has been linked to aberrant gene expression patterns seen in various diseases, making it a potential target for therapeutic interventions.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt search: MBD2 — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MBD2 - Gene search: MBD2 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MBD2 - Ensembl search: MBD2 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MBD2 - PubMed search: MBD2 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MBD2+antibody - Reactome search: MBD2 — Reactome — https:\/\/reactome.org\/content\/query?q=MBD2 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53046410740077,"sku":"F55113-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53046469820781,"sku":"F55113-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_072a9d99-9697-4d86-aad6-68a88fe87d12.jpg?v=1772000491","url":"https:\/\/www.ebiohippo.com\/products\/mbd2-antibody-methyl-cpg-binding-domain-protein-2-bha17128176","provider":"BioHippo","version":"1.0","type":"link"}