{"product_id":"mcpt4-antibody-mast-cell-protease-4-bha17128451","title":"Mcpt4 antibody \/ Mast cell protease 4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eMcpt4 antibody \/ Mast cell protease 4 is an antibody targeting \u003cstrong\u003eMCPT4\u003c\/strong\u003e, raised in \u003cstrong\u003eGoat\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MCPT4.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (goat origin); Goat Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Mouse.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e IHC-P, ELISA (peptide) (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eMcpt4 (Mast cell protease 4) is a protease enzyme that is predominantly found in mast cells, which are a type of white blood cell involved in the immune response. Proteases are enzymes that break down proteins into smaller peptides, and Mcpt4 is specifically known for its role in regulating inflammation and immune responses. Studies have shown that Mcpt4 can target a variety of proteins involved in the immune response, making it a key player in the body's defense against pathogens. One of the main functions of Mcpt4 is to regulate the release of pro-inflammatory mediators in the body. By targeting specific proteins involved in the immune response, Mcpt4 can help to modulate the body's inflammatory response, preventing excessive inflammation and tissue damage. In addition, Mcpt4 has also been shown to play a role in the activation of other immune cells, such as T cells and dendritic cells, further enhancing the body's ability to fight off pathogens and allergens. Due to its wide range of functions in the immune response, Mcpt4 has been implicated in a number of diseases: dysregulation of Mcpt4 levels has been linked to inflammatory disorders such as asthma, rheumatoid arthritis, and inflammatory bowel disease.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eImmunohistochemistry: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eELISA: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry P21812 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/P21812 - Gene search: MCPT4 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MCPT4 - Ensembl search: MCPT4 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MCPT4 - PubMed search: MCPT4 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MCPT4+antibody - Reactome search: MCPT4 — Reactome — https:\/\/reactome.org\/content\/query?q=MCPT4 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5 mg\/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide \/ 100 ug","offer_id":53046420963693,"sku":"R36503-100UG","price":475.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c8f871a6-4d0a-4c59-850b-33ca8d466ce5.jpg?v=1772000540","url":"https:\/\/www.ebiohippo.com\/products\/mcpt4-antibody-mast-cell-protease-4-bha17128451","provider":"BioHippo","version":"1.0","type":"link"}