{"product_id":"mda-mb-157-cell-bhc11101444","title":"MDA-MB-157 cell","description":"The MDA-MB-157 cell line is derived from a human breast carcinoma, specifically from a pleural effusion of a metastatic breast cancer patient. This cell line is extensively used in breast cancer research, particularly for studying the biology of triple-negative breast cancer (TNBC), a subtype that lacks expression of estrogen receptor (ER), progesterone receptor (PR), and HER2\/neu. MDA-MB-157 cells provide a valuable model for investigating the molecular mechanisms driving TNBC, as well as for testing potential therapeutic agents targeting this aggressive form of breast cancer.\nMDA-MB-157 cells exhibit an epithelial morphology and are characterized by their high metastatic potential. They express markers typical of basal-like breast cancer, including cytokeratins 5\/6 and epidermal growth factor receptor (EGFR). Researchers utilize MDA-MB-157 cells to explore key signaling pathways involved in TNBC progression, such as the PI3K\/Akt, MAPK, and Notch pathways. These cells are also employed in drug screening assays to evaluate the efficacy of chemotherapeutic agents, targeted therapies, and combination treatments. Additionally, MDA-MB-157 cells are used to study the mechanisms of drug resistance and to develop strategies to overcome it. The relevance of the MDA-MB-157 cell line in triple-negative breast cancer research underscores its importance in advancing our understanding of this challenging subtype of breast cancer and in developing more effective therapeutic approaches for TNBC patients.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101444\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950215688557,"sku":"305280","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/MDA-MB-157_20P5_2010x01_20171024_ch00_1920x1920_9f6c2970-6438-43b6-a8ba-5a8b4f9fb6b2.jpg?v=1769069144","url":"https:\/\/www.ebiohippo.com\/products\/mda-mb-157-cell-bhc11101444","provider":"BioHippo","version":"1.0","type":"link"}