{"product_id":"mdc1-phospho-ser513-rabbit-pab-bha15207082","title":"MDC1 (phospho Ser513) rabbit pAb","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003ePolyclonal Primary Antibody\u003c\/span\u003e\n\u003cp\u003eAnti-MDC1 (phospho Ser513) rabbit pAb antibody (, -derived) validated for use in multiple research applications. Targets MDC1 (phospho Ser513) rabbit pAb in validated species samples.\u003c\/p\u003e\n\n\n\u003ch2\u003eAntibody Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\n\u003c\/table\u003e\n\n\u003ch2\u003eScientific Background\u003c\/h2\u003e\n\u003cp\u003eThe protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2\/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and me…\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSubcellular Location:\u003c\/strong\u003e Nucleus . Chromosome . Associated with chromatin. Relocalizes to discrete nuclear foci following DNA damage, this requires 'Ser-139' phosphorylation of H2AX. Colocalizes with APTX at sites of DNA double-strand breaks.\u003c\/p\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\n\u003cstrong\u003eFor Research Use Only (RUO).\u003c\/strong\u003e Not intended for diagnostic or therapeutic procedures. Handle with standard laboratory biosafety precautions.\u003c\/div\u003e\n\u003ch2\u003eRelated Products\u003c\/h2\u003e\n\u003cp\u003eExplore our complete catalog of antibodies, ELISA kits, and life science research reagents at BioHippo.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"ELK Biotechnology","offers":[{"title":"50 uL","offer_id":53336233410925,"sku":"ES8081-50UL","price":192.4,"currency_code":"USD","in_stock":true},{"title":"100 uL","offer_id":53336236720493,"sku":"ES8081-100UL","price":322.4,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/ES8081-c-1.jpg?v=1778915808","url":"https:\/\/www.ebiohippo.com\/products\/mdc1-phospho-ser513-rabbit-pab-bha15207082","provider":"BioHippo","version":"1.0","type":"link"}