{"product_id":"mep1b-antibody-meprin-a-subunit-beta-bha17135256","title":"MEP1B Antibody \/ Meprin A subunit beta","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMEP1B Antibody \/ Meprin A subunit beta is a anti-MEP1B Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MEP1B\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IF, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe MEP1B antibody targets Meprin A subunit beta, a zinc metalloprotease encoded by the MEP1B gene. This enzyme is a member of the astacin family of metalloproteases and plays a key role in extracellular matrix remodeling, proteolytic processing of bioactive molecules, and epithelial homeostasis. Meprin A subunit beta combines with Meprin A subunit alpha or forms homodimers to generate active protease complexes localized at the plasma membrane. The MEP1B antibody provides researchers with a reliable means to study this protease's structure, function, and contribution to physiological and pathological processes.\u003cbr\u003e\u003cbr\u003eMeprin A subunit beta is synthesized as a zymogen and activated through proteolytic cleavage. Once active, it catalyzes the hydrolysis of various substrates, including extracellular matrix proteins such as collagen, fibronectin, and laminin, as well as cytokines and growth factors. These activities make Meprin A subunit beta a crucial regulator of tissue remodeling and inflammatory signaling. The MEP1B antibody allows scientists to detect this enzyme in epithelial cells, intestinal mucosa, and kidney proximal tubules, where it plays essential roles in maintaining barrier function and proteolytic balance.\u003cbr\u003e\u003cbr\u003eMutations or altered expression of MEP1B have been linked to inflammatory bowel disease, fibrosis, and cancer. Overexpression may enhance degradation of matrix components, facilitating tumor invasion or chronic tissue injury, while loss of function can impair epithelial integrity. The MEP1B antibody enables evaluation of these changes in expression patterns, helping clarify the connection between Meprin A subunit beta and disease pathology. Recent studies also suggest Meprin B's involvement in activation of interleukin precursors and complement components, further extending its biological significance.\u003cbr\u003e\u003cbr\u003eAt the molecular level, Meprin A subunit beta anchors to the plasma membrane via a transmembrane domain, orienting its catalytic site extracellularly. It interacts with glycoproteins and proteoglycans that influence its enzymatic specificity and activity. The MEP1B antibody is an effective tool for studying these protein�protein interactions using western blotting, immunohistochemistry, and immunofluorescence. Researchers frequently apply it in tissue-based assays to evaluate distribution and regulation in kidney, intestine, and liver, where the enzyme's expression is most prominent.\u003cbr\u003e\u003cbr\u003eBeyond normal physiology, Meprin A subunit beta has drawn attention for its potential contribution to neurodegenerative and fibrotic disorders. Proteolytic imbalance caused by excess Meprin activity can exacerbate inflammatory cascades and extracellular matrix turnover. The MEP1B antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MEP1B - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MEP1B - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MEP1B - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MEP1B - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MEP1B+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047285711213,"sku":"FY12353","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f5a3a47c-6204-4a90-a022-5c7c4e14a35f.jpg?v=1782237008","url":"https:\/\/www.ebiohippo.com\/products\/mep1b-antibody-meprin-a-subunit-beta-bha17135256","provider":"BioHippo","version":"1.0","type":"link"}