{"product_id":"metrnl-antibody-meteorin-like-protein-bha17136017","title":"METRNL Antibody \/ Meteorin-like protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMETRNL Antibody \/ Meteorin-like protein is a anti-METRNL Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e METRNL\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMETRNL antibody detects Meteorin-like protein, a secreted cytokine-like factor involved in energy metabolism, inflammation, and tissue regeneration. The UniProt recommended name is Meteorin-like protein (METRNL). Also known as Subfatin or Cometin, this glycoprotein modulates immune responses and promotes tissue repair through activation of anti-inflammatory macrophages and adipose thermogenesis.\u003cbr\u003e\u003cbr\u003eFunctionally, METRNL antibody identifies a 311-amino-acid secreted protein expressed in skeletal muscle, adipose tissue, and immune cells. METRNL is released during exercise and cold exposure, stimulating IL4-dependent macrophage activation that enhances energy expenditure and tissue remodeling. It also supports nerve regeneration and angiogenesis in damaged tissues.\u003cbr\u003e\u003cbr\u003eThe METRNL gene is located on chromosome 17q25.3 and encodes a protein structurally related to Meteorin (METRN). Its expression is induced by PGC1-alpha and STAT6 pathways, linking metabolic and immune regulation. METRNL functions as an intercellular communicator coordinating metabolic adaptation and immune homeostasis.\u003cbr\u003e\u003cbr\u003ePathologically, dysregulated METRNL expression is associated with metabolic disorders, obesity, and inflammation. Increased METRNL levels correlate with improved insulin sensitivity and energy balance, while reduced expression is linked to chronic inflammation and fibrosis. Research using METRNL antibody supports studies in metabolism, immunology, and regenerative biology.\u003cbr\u003e\u003cbr\u003eMETRNL antibody is suitable for ELISA, western blotting, and immunohistochemistry to detect circulating and tissue-localized Meteorin-like protein. \u003cbr\u003e\u003cbr\u003eStructurally, Meteorin-like protein contains a conserved alpha-helical fold characteristic of secreted growth factors. Its glycosylation and secretion signal peptide facilitate stable extracellular function. This antibody enables detailed study of METRNL's dual roles in metabolic control and immune modulation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=METRNL - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=METRNL - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=METRNL - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/METRNL - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=METRNL+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047312482669,"sku":"FY13115","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_925ade0b-b728-4a86-85b1-dfd8db50058d.jpg?v=1782237101","url":"https:\/\/www.ebiohippo.com\/products\/metrnl-antibody-meteorin-like-protein-bha17136017","provider":"BioHippo","version":"1.0","type":"link"}