{"product_id":"mettl17-antibody-methyltransferase-like-protein-17-bha17135357","title":"METTL17 Antibody \/ Methyltransferase-like protein 17","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMETTL17 Antibody \/ Methyltransferase-like protein 17 is a anti-METTL17 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA with listed reactivity in Human. Reported localization: Nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e METTL17\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMETTL17 antibody detects Methyltransferase-like protein 17, a mitochondrial RNA methyltransferase that contributes to the biogenesis and function of mitochondrial ribosomes. METTL17 catalyzes methylation of specific rRNA nucleotides, a process essential for proper ribosomal assembly and translational fidelity within mitochondria. This enzyme is part of the large family of S-adenosylmethionine-dependent methyltransferases, many of which regulate gene expression and RNA stability. The METTL17 antibody is widely used to study mitochondrial gene expression, translation, and the broader methyltransferase network involved in RNA modification and energy metabolism.\u003cbr\u003e\u003cbr\u003eMETTL17 is encoded by the METTL17 gene located on human chromosome 11q24.2. The protein localizes primarily to the mitochondrial matrix, where it associates with mitochondrial ribosomal subunits. Structurally, METTL17 contains a conserved Rossmann-like fold typical of class I methyltransferases, which facilitates binding to S-adenosyl-L-methionine (SAM), the universal methyl donor. Loss of METTL17 function impairs mitochondrial translation, leading to reduced oxidative phosphorylation and energy production.\u003cbr\u003e\u003cbr\u003eThe METTL17 antibody is useful in identifying both endogenous and overexpressed protein in cell lysates. Western blot typically reveals a single band around 44�46 kDa corresponding to full-length METTL17. Immunofluorescence analysis demonstrates mitochondrial localization with co-staining of mitochondrial markers such as TOM20 or COX IV. Functional studies have shown that METTL17 interacts with mitochondrial ribosomal RNA and components of the large ribosomal subunit, supporting its role in rRNA modification and mitoribosome assembly.\u003cbr\u003e\u003cbr\u003eDefects in METTL17-mediated methylation have been linked to disrupted mitochondrial respiration and altered cellular energy metabolism. In addition to its mitochondrial functions, METTL17 expression has been observed in proliferating cells and certain cancer tissues, suggesting potential links between RNA methylation and tumor metabolism.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=METTL17 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=METTL17 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=METTL17 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/METTL17 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=METTL17+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047286137197,"sku":"FY12454","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_6577fd5d-9700-473a-99d4-d0abaf8364e5.jpg?v=1782236988","url":"https:\/\/www.ebiohippo.com\/products\/mettl17-antibody-methyltransferase-like-protein-17-bha17135357","provider":"BioHippo","version":"1.0","type":"link"}