{"product_id":"mfap3l-antibody-microfibril-associated-protein-3-like-bha17135931","title":"MFAP3L Antibody \/ Microfibril-associated protein 3-like","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMFAP3L Antibody \/ Microfibril-associated protein 3-like is a anti-MFAP3L Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MFAP3L\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMFAP3L antibody detects Microfibril-associated protein 3-like, a cytoplasmic adaptor protein involved in cell signaling, cytoskeletal regulation, and extracellular matrix organization. The UniProt recommended name is Microfibril-associated protein 3-like (MFAP3L). Although its precise function remains under study, MFAP3L has been implicated in modulating cell adhesion and motility through protein-protein interactions within signaling networks.\u003cbr\u003e\u003cbr\u003eFunctionally, MFAP3L antibody identifies a 386-amino-acid cytoplasmic protein that associates with signaling molecules such as small GTPases, actin-binding proteins, and scaffolding complexes. MFAP3L contributes to cytoskeletal organization and may facilitate communication between extracellular matrix components and intracellular signaling pathways. Its expression has been linked to the regulation of cell migration, proliferation, and differentiation.\u003cbr\u003e\u003cbr\u003eThe MFAP3L gene is located on chromosome 4q32.1 and encodes a protein expressed in diverse tissues, including heart, lung, and skeletal muscle. MFAP3L shares sequence similarity with other microfibril-associated proteins but lacks classical extracellular matrix domains, suggesting a distinct intracellular regulatory role. It has been proposed to interact with Rho family GTPases and participate in actin cytoskeleton remodeling during cell movement and adhesion.\u003cbr\u003e\u003cbr\u003eIn cancer biology, elevated MFAP3L expression has been observed in certain epithelial tumors, including breast and colorectal cancer, where it may contribute to increased motility and invasive potential. Conversely, in cardiac and skeletal muscle, MFAP3L may assist in maintaining structural stability under mechanical stress. Although its specific mechanisms remain to be fully elucidated, MFAP3L appears to function at the interface of cytoskeletal dynamics and signal transduction.\u003cbr\u003e\u003cbr\u003eMFAP3L antibody is widely used in cell biology, oncology, and signal transduction research. It is suitable for immunoblotting, immunofluorescence, and co-immunoprecipitation to study MFAP3L localization and binding partners. This antibody supports research into cytoskeletal control, extracellular matrix signaling, and tumor progression. In developmental studies, MFAP3L serves as a marker of cytoplasmic microfibril-associated proteins involved in tissue structure and mechanical adaptation.\u003cbr\u003e\u003cbr\u003eStructurally, MFAP3L contains multiple coiled-coil regions that promote protein complex formation and interaction with cytoskeletal regulators. Its expression may be modulated by growth factor signaling and mechanical cues.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MFAP3L - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MFAP3L - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MFAP3L - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MFAP3L - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MFAP3L+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047309468013,"sku":"FY13029","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_7b024f84-09c4-4667-87ec-5992896a27a1.jpg?v=1782237084","url":"https:\/\/www.ebiohippo.com\/products\/mfap3l-antibody-microfibril-associated-protein-3-like-bha17135931","provider":"BioHippo","version":"1.0","type":"link"}