{"product_id":"mll3-antibody-kmt2c-bha17128191","title":"MLL3 Antibody \/ KMT2C","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eMLL3 Antibody \/ KMT2C is an antibody targeting \u003cstrong\u003eKMT2C\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e KMT2C.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Monoclonal (mouse origin); Clone 1686CT202.60.69; Mouse IgG1, kappa.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eKMT2C (Lysine N-methyltransferase 2C), also called MML3 (Myeloid\/lymphoid or mixed-lineage leukemia protein 3) is a histone methyltransferase, which means it adds methyl groups to histone proteins. This modification plays a critical role in controlling how genes are turned on and off. By regulating gene expression, KMT2C\/MML3 can influence various cellular processes, including cell growth, differentiation, and death. Research has also shown that mutations in the KMT2C gene are associated with the development of certain types of cancer. For example, mutations in KMT2C have been found in breast cancer, colorectal cancer, and other types of tumors. In addition to its role in cancer, KMT2C\/MML3 is also involved in DNA repair. This protein plays a crucial role in repairing damaged DNA, which is essential for maintaining genomic stability and preventing the development of genetic mutations.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry Q8NEZ4 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q8NEZ4 - Gene search: KMT2C — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=KMT2C - Ensembl search: KMT2C — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=KMT2C - PubMed search: KMT2C antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=KMT2C+antibody - Reactome search: KMT2C — Reactome — https:\/\/reactome.org\/content\/query?q=KMT2C --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.05 ml","offer_id":53046409920877,"sku":"F55128-0.05ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.2 ml","offer_id":53046467559789,"sku":"F55128-0.2ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_2d7e2354-547b-4c10-9c4b-ca6f705f5047.jpg?v=1772000491","url":"https:\/\/www.ebiohippo.com\/products\/mll3-antibody-kmt2c-bha17128191","provider":"BioHippo","version":"1.0","type":"link"}