{"product_id":"mml-1-cell-bhc11100733","title":"MML-1 cell","description":"The MML-1 cell line is a melanoma cell line derived from malignant melanoma. This cell line is used primarily to study melanoma biology, particularly the role of extracellular vesicles (EVs) in cell-to-cell communication and tumor progression. MML-1 cells release various subtypes of EVs, including exosomes, microvesicles, and apoptotic bodies, each carrying distinct RNA cargos, such as microRNAs (miRNAs) and other non-coding RNAs.\n\nStudies using MML-1 cells have demonstrated that exosomes released from these cells contain specific miRNAs like miR-214-3p, miR-199a-3p, and miR-155-5p, which are closely associated with melanoma progression and metastasis. These miRNAs are enriched in exosomes compared to other EV types and have been linked to important melanoma-related pathways, such as the regulation of the MAPK signaling pathway and tumor microenvironment interactions. Interestingly, comparisons of miRNA profiles from MML-1-derived exosomes with clinical samples of melanoma show a significant overlap, indicating the clinical relevance of this cell model in understanding melanoma progression.\n\nIn addition to miRNAs, MML-1 cells also release other non-coding RNAs such as small nucleolar RNAs (snoRNAs) and mitochondrial-associated transfer RNAs (mt-RNAs), which are differentially distributed among the EV subtypes. These findings highlight the MML-1 cell line's utility in studying the molecular mechanisms of melanoma, particularly how tumor cells communicate via EVs and influence their microenvironment.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100733\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950216966509,"sku":"300288","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/mml-1-_283_29_1920x1920_a2ec09ef-14f4-40e4-8026-bf8b71f752aa.jpg?v=1769069155","url":"https:\/\/www.ebiohippo.com\/products\/mml-1-cell-bhc11100733","provider":"BioHippo","version":"1.0","type":"link"}