{"product_id":"molt-3-cell-bhc11100567","title":"MOLT-3 cell","description":"MOLT-3 is a human T lymphoblast cell line derived from the peripheral blood of a 19-year-old male patient with acute lymphoblastic leukemia (ALL), specifically during a relapse following prior chemotherapy. This cell line was deposited by Dr. J. Minowada and is closely related to the MOLT-4 cell line, both originating from the same patient. MOLT-3 cells are widely used in research on immune system disorders, immunology, and immuno-oncology, making it an important model for studying T-cell leukemia and the immune response to various treatments. As a suspension cell line, MOLT-3 exhibits typical T-cell markers, including high expression of CD5 (97%) and CD7 (97%), along with CD1 and CD4. This cell line is also characterized by elevated terminal deoxynucleotidyl transferase (TdT) activity, which is commonly associated with immature lymphoid cells. MOLT-3 is valuable for studying T-cell differentiation, receptor signaling, and apoptosis, especially in the context of T-cell acute lymphoblastic leukemia (T-ALL). Due to its growth properties and well-characterized antigen expression, it is frequently utilized in drug screening and therapeutic research for leukemia treatments. Additionally, MOLT-3 cells do not produce immunoglobulins or contain detectable Epstein-Barr virus (EBV), which makes them an excellent model for studying T-cell-specific pathways without interference from B-cell characteristics. The cell line's response to various experimental manipulations further enhances its application in immuno-oncology, particularly for exploring potential therapeutic interventions targeting T-cell malignancies.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100567\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950217130349,"sku":"300116","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/MOLT-3_20waKo_20P1_2020x01_20080525_ch00_1920x1920_e0f8657d-4d5d-4b5f-878b-ca7e18804b31.jpg?v=1769069156","url":"https:\/\/www.ebiohippo.com\/products\/molt-3-cell-bhc11100567","provider":"BioHippo","version":"1.0","type":"link"}