{"product_id":"molt-4-cell-bhc11100657","title":"MOLT-4 cell","description":"MOLT-4 is a T lymphoblast cell line derived from the peripheral blood of a 19-year-old male patient with Acute lymphoblastic leukemia (ALL) in relapse in 1971. It is a sister cell line of MOLT-3, while MOLT-4 shows an unusual T-cell antigen receptor gamma-chain gene (T-gamma) rearrangement. MOLT-4 cells have a doubling time of around 30 hours, grow in suspension, and are tumorigenic in untreated nude mice, anti-lymphocyte serum-treated mice, and x-irradiated mice.\nMOLT-4 cells have a hypertetraploid chromosome number with the modal chromosome number of 95 occurring in 24% of cells but show stable and recurrent structural abnormalities of chromosomes and longer telomere length. MOLT-4 expresses a variety of T cell markers including CD1, CD2, CD3A, CD3B, CD3C, CD4, CD5, CD6, and CD7. They also express high levels of terminal deoxynucleotidyl transferase (TdT).\nThe MOLT-4 cell line does not produce immunoglobulin or Epstein-Barr virus. The patient from whom the cells were derived had received prior multidrug chemotherapy. There is a G -\u0026gt; A mutation at codon 248 of the p53 gene, and P53 is not expressed. The line was initially contaminated with mycoplasma but has since been cured with antibiotics.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100657\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950217163117,"sku":"300115","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/MOLT-4_20WaKo_20P1_2020x01_20111125_1920x1920_716b91f8-7934-4d60-9596-8623af9b7a31.png?v=1769069158","url":"https:\/\/www.ebiohippo.com\/products\/molt-4-cell-bhc11100657","provider":"BioHippo","version":"1.0","type":"link"}