{"product_id":"mouse-serine-threonine-protein-kinase-11-stk11-elisa-kit-bhe13705429","title":"Mouse Serine\/threonine-protein kinase 11 (STK11) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eMouse Serine\/threonine-protein kinase 11 (STK11) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse STK11. No significant cross-reactivity or interference between Mouse STK11 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eLKB1 is a primary upstream kinase of adenine monophosphate-activated protein kinase (AMPK), a necessary element in cell metabolism that is required for maintaining energy homeostasis. It is now clear that LKB1 exerts its growth suppressing effects by activating a group of other ~14 kinases, comprising AMPK and AMPK-related kinases. Activation of AMPK by LKB1 suppresses growth and proliferation when energy and nutrient levels are scarce. Activation of AMPK-related kinases by LKB1 plays vital roles maintaining cell polarity thereby inhibiting inappropriate expansion of tumour cells. A picture from current research is emerging that loss of LKB1 leads to disorganization of cell polarity and facilitates tumour growth under energetically unfavorable conditions.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338656801133,"sku":"KTE70269-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338893877613,"sku":"KTE70269-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338893910381,"sku":"KTE70269-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338893943149,"sku":"KTE70269-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE70269.png?v=1778954829","url":"https:\/\/www.ebiohippo.com\/products\/mouse-serine-threonine-protein-kinase-11-stk11-elisa-kit-bhe13705429","provider":"BioHippo","version":"1.0","type":"link"}