{"product_id":"mouse-signal-transducer-and-activator-of-transcription-4-stat4-elisa-kit-bhe13705425","title":"Mouse Signal transducer and activator of transcription 4 (STAT4) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eMouse Signal transducer and activator of transcription 4 (STAT4) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse STAT4. No significant cross-reactivity or interference between Mouse STAT4 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eSTAT4 is phosphorylated in response to interleukin-12  and is essential for IL12 signal transduction. For further information on STATs. STAT4 and STAT1, which both map to chromosome 2q32, may have arisen via a tandem gene duplication. However, STAT1 was expressed ubiquitously, whereas STAT4 was expressed in specific tissues, including spleen, heart, brain, peripheral blood cells, and testis. STAT4 expression was drastically increased in T cells following treatment with a DNA methyltransferase inhibitor. Truncation of methylation sites in the proximal regulatory elements of the STAT4 promoter markedly enhanced transcriptional activity. The N-terminal protein interaction domain (N domain) of STAT4 is required for STAT4 activation after IL12 signaling.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338656604525,"sku":"KTE70265-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338892009837,"sku":"KTE70265-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338892042605,"sku":"KTE70265-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338892075373,"sku":"KTE70265-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE70265.png?v=1778954829","url":"https:\/\/www.ebiohippo.com\/products\/mouse-signal-transducer-and-activator-of-transcription-4-stat4-elisa-kit-bhe13705425","provider":"BioHippo","version":"1.0","type":"link"}