{"product_id":"mouse-soluble-toll-like-receptor-4-stlr4-elisa-kit-bhe13705370","title":"Mouse Soluble Toll-like Receptor 4 (sTLR4) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eMouse Soluble Toll-like Receptor 4 (sTLR4) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse TLR4. No significant cross-reactivity or interference between Mouse TLR4 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eTlr4 belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll\/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by Tlr4 mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in Tlr4 display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338655097197,"sku":"KTE70210-48T","price":359.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338886701421,"sku":"KTE70210-96T","price":619.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338886734189,"sku":"KTE70210-96TX5","price":2809.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338886766957,"sku":"KTE70210-96TX50","price":26209.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/mouse-soluble-toll-like-receptor-4-stlr4-elisa-kit-bhe13705370","provider":"BioHippo","version":"1.0","type":"link"}