{"product_id":"mouse-tm2-domain-containing-protein-1-tm2d1-elisa-kit-bhe13705366","title":"Mouse TM2 domain-containing protein 1 (TM2D1) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eMouse TM2 domain-containing protein 1 (TM2D1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse TM2D1. No significant cross-reactivity or interference between Mouse TM2D1 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eTM2D1 is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death.BBP bound the 42-amino acid form of human beta-amyloid peptide in vitro with high affinity and specificity. Expression of a signaling-deficient dominant-negative BBP mutant suppressed sensitivity of human Ntera-2 neurons to beta-amyloid-mediated toxicity.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338654966125,"sku":"KTE70206-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338886308205,"sku":"KTE70206-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338886340973,"sku":"KTE70206-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338886373741,"sku":"KTE70206-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE70206.png?v=1778954823","url":"https:\/\/www.ebiohippo.com\/products\/mouse-tm2-domain-containing-protein-1-tm2d1-elisa-kit-bhe13705366","provider":"BioHippo","version":"1.0","type":"link"}