{"product_id":"mpo-antibody-myeloperoxidase-bha17135756","title":"MPO Antibody \/ Myeloperoxidase","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMPO Antibody \/ Myeloperoxidase is a anti-MPO Rabbit antibody Recombinant Rabbit Monoclonal clone 32M13 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MPO\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32M13, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMPO antibody detects myeloperoxidase, an abundant heme-containing enzyme encoded by the MPO gene. Myeloperoxidase is stored in the azurophilic granules of neutrophils and monocytes and plays a central role in host defense by generating reactive oxidants. Upon activation, myeloperoxidase catalyzes the conversion of hydrogen peroxide and chloride ions into hypochlorous acid, a potent antimicrobial oxidant that contributes to pathogen killing during the respiratory burst.\u003cbr\u003e\u003cbr\u003eMyeloperoxidase has long been used as a histochemical marker for neutrophil activity. Detection with MPO antibody reveals the distribution and abundance of neutrophils in tissues, aiding in studies of infection, inflammation, and immune-mediated disorders. Elevated levels of myeloperoxidase are also associated with chronic inflammatory diseases, including atherosclerosis and rheumatoid arthritis. In cardiovascular research, plasma MPO concentration is studied as a potential biomarker for coronary artery disease and acute coronary syndromes.\u003cbr\u003e\u003cbr\u003eBeyond host defense, excessive or misplaced MPO activity can cause tissue injury by generating reactive oxygen species and halogenated products. This has been implicated in neurodegenerative disorders such as Parkinson's and Alzheimer's disease. Using MPO antibody, researchers are able to map protein distribution in affected tissues and evaluate its contribution to disease progression.\u003cbr\u003e\u003cbr\u003eIn oncology, myeloperoxidase serves as a lineage marker distinguishing myeloid leukemias from lymphoid subtypes. Immunohistochemical detection with MPO antibody remains a diagnostic tool in hematopathology, where positive staining confirms myeloid origin. Flow cytometry and ELISA-based detection further expand applications of this antibody in clinical and research settings.\u003cbr\u003e\u003cbr\u003eBecause myeloperoxidase contributes to both protective immunity and pathological inflammation, it represents a dual-interest protein for immunologists, pathologists, and cardiovascular researchers.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MPO - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MPO - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MPO - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MPO - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MPO+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047303930221,"sku":"FY12854","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_66bd8bd6-c892-41f7-9cc7-9dffedac3d79.jpg?v=1772019355","url":"https:\/\/www.ebiohippo.com\/products\/mpo-antibody-myeloperoxidase-bha17135756","provider":"BioHippo","version":"1.0","type":"link"}