{"product_id":"mras-antibody-ras-related-protein-m-ras-bha17135705","title":"MRAS Antibody \/ Ras-related protein M-Ras","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMRAS Antibody \/ Ras-related protein M-Ras is a anti-MRAS Rabbit antibody Recombinant Rabbit Monoclonal clone 29M72 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MRAS\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29M72, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMRAS antibody detects Ras related protein M Ras, encoded by the MRAS gene. This protein is also called muscle Ras oncogene homolog, R Ras3, and M Ras. MRAS belongs to the Ras superfamily of small GTP binding proteins, which function as molecular switches in signal transduction. Like other Ras family members, MRAS cycles between an inactive GDP bound form and an active GTP bound form, relaying signals from cell surface receptors to downstream effectors that control proliferation, differentiation, and survival.\u003cbr\u003e\u003cbr\u003eMRAS antibody is widely applied in cancer research, developmental biology, and signaling studies. MRAS differs from classical Ras proteins in sequence and regulation, giving it distinct functions. It interacts with SHOC2 and PP1c in a complex that regulates MAPK pathway activation. MRAS also contributes to neuronal differentiation, cardiac development, and vascular biology. By detecting MRAS, researchers can investigate how this atypical Ras family protein integrates signaling across tissues.\u003cbr\u003e\u003cbr\u003eApplications of MRAS antibody include western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects MRAS expression in cell lysates, immunohistochemistry maps its expression in tissues such as brain and heart, and immunofluorescence highlights subcellular localization at the plasma membrane and endomembranes. These methods provide powerful tools for exploring MRAS biology in normal and disease contexts.\u003cbr\u003e\u003cbr\u003eMutations in MRAS are rare compared to KRAS or HRAS, but dysregulated expression has been linked to cancer. MRAS activity supports cell proliferation and transformation in lung, gastric, and hematologic malignancies. It also modulates epithelial mesenchymal transition and cell migration. By applying MRAS antibody, scientists can evaluate MRAS as a potential biomarker and therapeutic target.\u003cbr\u003e\u003cbr\u003eIn cardiovascular biology, MRAS regulates vascular smooth muscle cell signaling and contributes to cardiac morphogenesis. Its expression in neuronal tissues links it to axonal guidance and synaptic plasticity. MRAS is also involved in T cell receptor signaling, suggesting roles in adaptive immunity. The antibody therefore supports research across multiple physiological systems.\u003cbr\u003e\u003cbr\u003eTherapeutically, targeting MRAS signaling is under investigation, particularly its cooperation with SHOC2 in Ras MAPK activation. Detection of MRAS with antibody based assays provides biomarkers for drug development and pathway modulation. MRAS antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MRAS - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MRAS - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MRAS - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MRAS - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MRAS+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047302652269,"sku":"FY12803","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5f9ae8cf-c174-4251-9b0a-a04ac50d3e3b.jpg?v=1772019345","url":"https:\/\/www.ebiohippo.com\/products\/mras-antibody-ras-related-protein-m-ras-bha17135705","provider":"BioHippo","version":"1.0","type":"link"}