{"product_id":"msc-p5-cell-bhc11100741","title":"MSC-P5 cell","description":"The MSCP5 cell line, derived from murine skin keratinocytes, represents a vital tool for research in dermatology and cellular biology. This line is characterized by its robust expression of prostaglandin-H synthase 2 (PGHS-2), also known as cyclooxygenase-2 (COX-2), an enzyme critical in the prostaglandin biosynthesis pathway, which plays a pivotal role in inflammation and wound healing processes. Notably, MSCP5 cells exhibit a pronounced induction of PGHS-2 expression upon stimulation with phorbol 12-myristate 13-acetate (PMA), mimicking the cellular response to inflammatory conditions and hyperproliferative states of the epidermis.\nThis cell line offers a unique model for investigating the regulation of COX-2 expression and its implications in skin pathophysiology, including inflammation and carcinogenesis. The PMA-induced upregulation of PGHS-2 in MSCP5 cells provides a valuable system for studying the molecular mechanisms of keratinocyte response to inflammatory stimuli, the role of prostaglandins in skin diseases, and the potential therapeutic targeting of COX-2 in dermatological conditions.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100741\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950217392493,"sku":"400294","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/msc-p5-_281_29_1920x1920_883da2e8-0c1e-422e-a154-c3e300b43c21.jpg?v=1769069158","url":"https:\/\/www.ebiohippo.com\/products\/msc-p5-cell-bhc11100741","provider":"BioHippo","version":"1.0","type":"link"}