{"product_id":"msra-antibody-methionine-sulfoxide-reductase-a-bha17135811","title":"MSRA Antibody \/ Methionine sulfoxide reductase A","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMSRA Antibody \/ Methionine sulfoxide reductase A is a anti-MSRA Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MSRA\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMSRA antibody detects Methionine sulfoxide reductase A, a key antioxidant enzyme that repairs oxidized methionine residues in proteins, restoring their function and protecting cells from oxidative stress. Encoded by the MSRA gene on chromosome 8p23.1, this enzyme belongs to the methionine sulfoxide reductase family and plays an essential role in maintaining protein integrity and cellular redox balance. By catalyzing the reduction of methionine-S-sulfoxide back to methionine, MSRA reverses oxidative damage caused by reactive oxygen species (ROS).\u003cbr\u003e\u003cbr\u003eStructurally, MSRA is a 235-amino-acid protein of approximately 26 kilodaltons containing a thioredoxin-like catalytic domain with a conserved cysteine residue essential for redox cycling. It exists in multiple isoforms localized to cytosolic, mitochondrial, and peroxisomal compartments, ensuring broad cellular protection. The enzyme utilizes thioredoxin as an electron donor, enabling reduction of oxidized methionine residues in structural and metabolic proteins.\u003cbr\u003e\u003cbr\u003eThe MSRA antibody is widely used in oxidative stress, neurodegeneration, and aging research to study redox regulation, protein repair, and cellular stress defense. Western blot analysis detects a 26 kilodalton band corresponding to MSRA, while immunofluorescence shows strong cytoplasmic and mitochondrial staining. This antibody provides a powerful tool for analyzing antioxidant defense systems and understanding how methionine oxidation influences cellular resilience and disease processes.\u003cbr\u003e\u003cbr\u003eFunctionally, MSRA contributes to cellular longevity by maintaining the functionality of oxidatively damaged proteins, particularly in mitochondria where ROS production is high. It has been implicated in protecting against neurodegenerative disorders, cardiovascular diseases, and metabolic stress. Loss of MSRA activity accelerates protein oxidation and mitochondrial dysfunction, whereas its overexpression enhances stress tolerance and lifespan in model organisms. The MSRA antibody supports research into oxidative repair mechanisms, antioxidant therapeutics, and the molecular basis of redox regulation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MSRA - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MSRA - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MSRA - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MSRA - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MSRA+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047306322285,"sku":"FY12909","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_62b01651-79ef-4a21-8eb0-536df866d7e2.jpg?v=1782237059","url":"https:\/\/www.ebiohippo.com\/products\/msra-antibody-methionine-sulfoxide-reductase-a-bha17135811","provider":"BioHippo","version":"1.0","type":"link"}