{"product_id":"msrb3-antibody-methionine-sulfoxide-reductase-b3-bha17135469","title":"MSRB3 Antibody \/ Methionine sulfoxide reductase B3","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMSRB3 Antibody \/ Methionine sulfoxide reductase B3 is a anti-MSRB3 Rabbit antibody Recombinant Rabbit Monoclonal clone 29M98 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MSRB3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29M98, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMSRB3 antibody detects methionine sulfoxide reductase B3, a repair enzyme encoded by the MSRB3 gene. MSRB3 belongs to the methionine sulfoxide reductase family, which reduces oxidized methionine residues back to methionine. By repairing oxidatively damaged proteins, MSRB3 contributes to redox regulation, protein quality control, and cellular defense against oxidative stress. MSRB3 exists in two isoforms localized to mitochondria and endoplasmic reticulum, reflecting its broad role in maintaining proteostasis.\u003cbr\u003e\u003cbr\u003eMSRB3 antibody is widely applied in studies of redox biology, aging, and hearing research. Mutations in MSRB3 cause autosomal recessive nonsyndromic hearing loss due to impaired protection of auditory cells against oxidative damage. By detecting MSRB3, researchers can explore how oxidative stress contributes to sensory degeneration and how protein repair mechanisms maintain tissue health.\u003cbr\u003e\u003cbr\u003e In western blot assays, MSRB3 antibody detects protein bands of expected molecular weight in mitochondrial and ER fractions. Immunohistochemistry highlights expression in cochlea, brain, and liver, while immunofluorescence demonstrates subcellular localization to mitochondria and ER networks. These applications provide detailed analysis of MSRB3 distribution and function.\u003cbr\u003e\u003cbr\u003eMSRB3 contributes to cellular stress resistance by repairing oxidized methionine in metabolic and structural proteins. Its protective functions extend to aging, neurodegeneration, and metabolic disease. Dysregulation of MSRB3 has been associated with reduced stress tolerance, enhanced apoptosis, and impaired organ function. By applying MSRB3 antibody, scientists can investigate therapeutic strategies aimed at enhancing protein repair pathways.\u003cbr\u003e\u003cbr\u003eMSRB3 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MSRB3 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MSRB3 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MSRB3 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MSRB3 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MSRB3+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047291904365,"sku":"FY12566","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_88bdfff7-d6fc-4364-b3c7-dce2dd09381e.jpg?v=1772019310","url":"https:\/\/www.ebiohippo.com\/products\/msrb3-antibody-methionine-sulfoxide-reductase-b3-bha17135469","provider":"BioHippo","version":"1.0","type":"link"}