{"product_id":"muc1-antibody-mucin-1-bha17116417","title":"MUC1 Antibody \/ Mucin-1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMAb VU-4H5 reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The dominant epitope of MAb VU-4H5 is APDTR as established with epitope fingerprinting. VU-4H5 preferentially binds to under-glycosylated tumor MUC1. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is upregulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion. Antibody to MUC1 is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.\u003c\/p\u003e\u003cp\u003eThis anti-MUC1 antibody is supplied as Purified (Mouse, Monoclonal (mouse origin), clone VU-4H5, Mouse IgG1, kappa, Unconjugated) and is designed to support common target-detection workflows after the on-page specifications.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MUC1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLocalization:\u003c\/strong\u003e Cytoplasmic and cell surface\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (listed):\u003c\/strong\u003e WB, FACS, IF, IHC-P\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConjugate:\u003c\/strong\u003e Unconjugated\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClone and antibody class:\u003c\/strong\u003e Monoclonal (mouse origin), clone VU-4H5, Mouse IgG1, kappa\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eBecause antibody performance can depend on epitope context, sample preparation, and biological state, interpret signals using appropriate controls and orthogonal evidence when possible.\u003c\/p\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003eMUC1 is referenced in public gene\/protein resources (e.g., UniProt and NCBI Gene), which provide curated names\/synonyms, protein features, and pathway context. When designing assays, consider potential isoforms, post-translational modifications, and cell-type specific expression that may influence observed signal.\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eProfiling MUC1 expression across model systems, perturbations, and time points to support mechanistic hypotheses.\u003c\/li\u003e\n\u003cli\u003eCombining antibody-based detection with multi-omics or imaging readouts to link MUC1 signal with phenotype.\u003c\/li\u003e\n\u003cli\u003eUsing well-matched controls (isotype controls, genetic perturbations, or independent reagents) to strengthen interpretation of target-associated signal.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eWB\u003c\/li\u003e\n\u003cli\u003eFACS\u003c\/li\u003e\n\u003cli\u003eIF\u003c\/li\u003e\n\u003cli\u003eIHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eUse the listed applications as a starting point and tailor experimental design to your sample type and readout requirements.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecificity considerations:\u003c\/strong\u003e closely related family members, isoforms, or PTMs can affect apparent specificity; confirm with independent approaches when critical.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eControls:\u003c\/strong\u003e include negative controls and, when feasible, genetic or pharmacologic perturbations to support target attribution in your system.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecies and sample context:\u003c\/strong\u003e differences in sequence, expression, fixation, or extraction conditions can change signal behavior across models.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProt Knowledgebase — UniProt — https:\/\/www.uniprot.org\/ - NCBI Gene — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/ - Ensembl Genome Browser — EMBL-EBI — https:\/\/www.ensembl.org\/ - Human Protein Atlas — SciLifeLab\/KTH — https:\/\/www.proteinatlas.org\/ - Gene Ontology — GO Consortium — https:\/\/geneontology.org\/ - Reactome Pathway Database — Reactome — https:\/\/reactome.org\/ - PubMed — NCBI — https:\/\/pubmed.ncbi.nlm.nih.gov\/ --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.2 mg\/ml in 1X PBS with 0.1 mg\/ml BSA (US sourced) and 0.05% sodium azide \/ 100 ug","offer_id":53045176009069,"sku":"V7510-100UG","price":559.0,"currency_code":"USD","in_stock":true},{"title":"0.2 mg\/ml in 1X PBS with 0.1 mg\/ml BSA (US sourced) and 0.05% sodium azide \/ 20 ug","offer_id":53045340864877,"sku":"V7510-20UG","price":259.0,"currency_code":"USD","in_stock":true},{"title":"Prediluted in 1X PBS, 0.1 mg\/ml BSA (US sourced), 0.05% sodium azide; *For IHC use only* \/ 7 ml","offer_id":53045340897645,"sku":"V7510IHC-7ML","price":559.0,"currency_code":"USD","in_stock":true},{"title":"1 mg\/ml in 1X PBS; BSA free, sodium azide free \/ 100 ug","offer_id":53045340930413,"sku":"V7510SAF-100UG","price":559.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_10fc57be-5aae-43aa-bc50-fa693896467f.jpg?v=1771953132","url":"https:\/\/www.ebiohippo.com\/products\/muc1-antibody-mucin-1-bha17116417","provider":"BioHippo","version":"1.0","type":"link"}