{"product_id":"mx1-antibody-mxa-myxovirus-resistance-protein-1-bha17135930","title":"MX1 Antibody \/ MxA \/ Myxovirus resistance protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMX1 Antibody \/ MxA \/ Myxovirus resistance protein 1 is a anti-MX1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm, nucleus.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MX1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMX1 antibody detects Myxovirus resistance protein 1, a dynamin-like GTPase that mediates antiviral defense against a wide range of RNA and DNA viruses. The UniProt recommended name is Interferon-induced GTP-binding protein Mx1 (MX1). Also known as MxA in humans, this protein is one of the best-characterized interferon-stimulated genes (ISGs) and represents a central effector of type I and type III interferon antiviral activity.\u003cbr\u003e\u003cbr\u003eFunctionally, MX1 antibody identifies a 662-amino-acid cytoplasmic GTPase that self-assembles into oligomeric rings and tubular structures upon activation. MX1 binds and traps viral nucleocapsids and replication complexes, blocking viral genome transcription and replication. Its antiviral spectrum includes orthomyxoviruses (such as influenza A), paramyxoviruses, bunyaviruses, and other RNA viruses, as well as certain DNA viruses. MX1 activity is GTP-dependent and requires oligomerization for full antiviral efficacy.\u003cbr\u003e\u003cbr\u003eThe MX1 gene is located on chromosome 21q22.3 and is transcriptionally induced by type I interferons (IFN-alpha and IFN-beta) and type III interferons (IFN-lambda). MX1 localizes to the cytoplasm and associates with intracellular membranes where viral replication occurs. Upon interferon stimulation, MX1 accumulates rapidly and remains active for several hours, providing a robust first-line defense during viral infection. Its antiviral mechanism includes sequestering viral nucleoproteins, blocking uncoating, and preventing the assembly of viral polymerase complexes.\u003cbr\u003e\u003cbr\u003eIn immunology, MX1 serves as a molecular signature of interferon pathway activation and is frequently used as a biomarker for assessing antiviral or autoimmune responses. Elevated MX1 expression is characteristic of viral infections, systemic lupus erythematosus, and interferonopathies. In contrast, genetic polymorphisms affecting MX1 activity can reduce viral resistance and modulate disease susceptibility. MX1 also contributes to innate immunity in epithelial barriers, liver, and lung tissues, providing localized protection against viral entry and replication.\u003cbr\u003e\u003cbr\u003eMX1 antibody is widely used in virology, immunology, and interferon signaling research. It is suitable for western blotting, immunofluorescence, and immunohistochemistry to detect MX1 expression following viral infection or interferon treatment. This antibody enables monitoring of innate immune activation and evaluation of interferon pathway modulators. In pathology, MX1 staining is used to confirm interferon signature activation in autoimmune and inflammatory diseases.\u003cbr\u003e\u003cbr\u003eStructurally, MX1 belongs to the dynamin superfamily of large GTPases, with conserved GTP-binding, stalk, and oligomerization domains. The protein hydrolyzes GTP to induce conformational changes required for viral entrapment.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MX1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MX1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MX1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MX1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MX1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047310221677,"sku":"FY13028","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_89b37079-0b79-4dcf-8f2a-77ae047ddf04.jpg?v=1782237083","url":"https:\/\/www.ebiohippo.com\/products\/mx1-antibody-mxa-myxovirus-resistance-protein-1-bha17135930","provider":"BioHippo","version":"1.0","type":"link"}