{"product_id":"mybbp1a-antibody-myb-binding-protein-1a-bha17135616","title":"MYBBP1A Antibody \/ Myb-binding protein 1A","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMYBBP1A Antibody \/ Myb-binding protein 1A is a anti-MYBBP1A Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA with listed reactivity in Mouse, Rat. Reported localization: Nucleus, Nucleolus, Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MYBBP1A\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMYBBP1A antibody detects Myb-binding protein 1A, a nucleolar transcriptional regulator that modulates gene expression, chromatin structure, and cell cycle progression. Encoded by the MYBBP1A gene on chromosome 17p13.3, this large nuclear protein was originally identified through its interaction with the Myb oncoprotein, but it also binds multiple transcription factors including p53, NF?B, and STAT3. MYBBP1A contains several acidic and coiled-coil domains that facilitate protein-protein interactions and nucleolar localization sequences that target it to the nucleolus under normal growth conditions. It functions as both a transcriptional coactivator and corepressor, integrating stress responses with cell cycle control.\u003cbr\u003e\u003cbr\u003eMYBBP1A plays a key role in ribosome biogenesis and nucleolar stress signaling. Upon cellular stress or energy depletion, MYBBP1A translocates from the nucleolus to the nucleoplasm, where it enhances p53 acetylation and activation, promoting cell cycle arrest and apoptosis. It also suppresses c-Myb-driven transcription to prevent uncontrolled proliferation. Through these mechanisms, MYBBP1A acts as a tumor suppressor and regulator of growth arrest. Depletion of MYBBP1A leads to impaired rRNA processing and increased genomic instability. Dysregulation of its expression has been reported in renal carcinoma, hepatocellular carcinoma, and hematologic malignancies.\u003cbr\u003e\u003cbr\u003eThe MYBBP1A antibody is used in cancer biology and transcriptional regulation studies to detect Myb-binding protein 1A localization and abundance. Western blot analysis typically identifies a ~150 kilodalton band, while immunofluorescence shows predominant nucleolar staining with redistribution upon stress. Because MYBBP1A interacts with both histone-modifying enzymes and transcriptional machinery, it is a critical factor for understanding nucleolar function and epigenetic regulation. The antibody is effective in chromatin immunoprecipitation, immunohistochemistry, and nuclear fractionation assays. The MYBBP1A antibody therefore supports research on tumor suppression, transcriptional control, and nucleolar biology.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MYBBP1A - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MYBBP1A - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MYBBP1A - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MYBBP1A - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MYBBP1A+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047298326893,"sku":"FY12713","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_854b57e0-3c00-47a5-86ba-050d6b229fc4.jpg?v=1782237033","url":"https:\/\/www.ebiohippo.com\/products\/mybbp1a-antibody-myb-binding-protein-1a-bha17135616","provider":"BioHippo","version":"1.0","type":"link"}