{"product_id":"myh2-antibody-myosin-heavy-chain-2-bha17135479","title":"MYH2 Antibody \/ Myosin heavy chain 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMYH2 Antibody \/ Myosin heavy chain 2 is a anti-MYH2 Rabbit antibody Recombinant Rabbit Monoclonal clone 32M67 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MYH2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32M67, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMYH2 antibody detects myosin heavy chain 2, encoded by the MYH2 gene. MYH2 is a skeletal muscle myosin isoform expressed in type IIa fast oxidative fibers. Myosin heavy chains are motor proteins that convert ATP hydrolysis into mechanical force, driving actin-based muscle contraction. MYH2 provides intermediate contractile velocity and fatigue resistance, making it a key determinant of muscle performance.\u003cbr\u003e\u003cbr\u003eMYH2 antibody is widely applied in muscle physiology, pathology, and developmental biology research. Detection of MYH2 expression distinguishes type IIa fibers from other fiber types, supporting studies of muscle composition and plasticity. In clinical research, MYH2 expression patterns are examined in muscular dystrophy, myopathies, and age-related sarcopenia. By detecting MYH2, researchers can assess muscle adaptation to exercise, disease, and therapeutic interventions.\u003cbr\u003e\u003cbr\u003e Western blot assays detect MYH2 protein in skeletal muscle extracts. Immunohistochemistry maps MYH2 distribution within muscle cross sections, enabling identification of fiber type composition. Immunofluorescence highlights sarcomeric localization, providing high-resolution visualization of contractile architecture.\u003cbr\u003e\u003cbr\u003eMYH2 mutations cause autosomal dominant myopathy characterized by progressive muscle weakness, abnormal fiber morphology, and impaired contractility. Detection with MYH2 antibody supports genetic and pathological studies of this disease. Additionally, MYH2 is a marker of regenerative fibers and is used to study developmental myogenesis. By applying MYH2 antibody, scientists can investigate both physiological and pathological aspects of skeletal muscle biology.\u003cbr\u003e\u003cbr\u003eBeyond skeletal muscle, MYH2 research contributes to understanding of biomechanics, metabolic regulation, and aging. Differences in MYH2 expression across individuals and conditions reflect muscle plasticity and adaptation. The antibody therefore provides a critical reagent for both basic science and translational studies in muscle biology.\u003cbr\u003e\u003cbr\u003eMYH2 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MYH2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MYH2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MYH2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MYH2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MYH2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047292592493,"sku":"FY12576","price":449.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/myh2-antibody-myosin-heavy-chain-2-bha17135479","provider":"BioHippo","version":"1.0","type":"link"}